Now showing items 21-34 of 34

  • Effects of Altered Prenatal Hormonal Environment on Expression of Autoimmune Disease in NZB/NZW Mice 

    Walker, Sara E.; Keisler, Lydia White; Caldwell, Charles W., M.D.; Kier, Ann B.; vom Saal, Frederick S. (National Institute of Environmental Health Sciences, 1996)
    F1 hybrid New Zealand Black (NZB) x New Zealand White (NZW) (NZB/NZW) mice spontaneously develop an autoimmune disease analogous to systemic lupus erythematosus (SLE) . Testosterone exerts a powerful suppressive effect on ...
  • Coregulation of Ion Channel Conductances Preserves Output in a Computational Model of a Crustacean Cardiac Motor Neuron 

    Ball, John M., 1982-; Franklin, Clarence C.; Tobin, Anne-Elise; Schulz, David; Nair, Satish S., 1960- (Society for Neuroscience, 2010)
    Similar activity patterns at both neuron and network levels can arise from different combinations of membrane and synaptic conductance values. A strategy by which neurons may preserve their electrical output is via cell ...
  • Low Phytoestrogen Levels in Feed Increase Fetal Serum Estradiol Resulting in the “Fetal Estrogenization Syndrome” and Obesity in CD-1 Mice 

    Ruhlen, Rachel L.; Howdeshell, Kembra L. (Kembra Lynne), 1968-; Mao, Jiude; Taylor, Julia A.; Bronson, F. H.; Newbold, Retha R.; Welshons, Wade V.; vom Saal, Frederick S. (Environmental Health Perspectives, 2008)
    Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful. We compared reproductive and metabolic characteristics ...
  • Estradiol and Bisphenol A Stimulate Androgen Receptor and Estrogen Receptor Gene Expression in Fetal Mouse Prostate Mesenchyme Cells 

    Richter, Catherine A.; Taylor, Julia A.; Ruhlen, Rachel L.; vom Saal, Frederick S. (Environmental Health Perspectives, 2007)
    Hormonal alterations during development have lifelong effects on the prostate gland. Endogenous estrogens, including 17β-estradiol (E2), and synthetic estrogenic endocrine disruptors, such as bisphenol A (BPA), have similar ...
  • Biogenesis of the Protein Storage Vacuole Crystalloid 

    Jiang, Liwen; Phillips, Thomas; Rogers, Sally W.; Rogers, John C., 1949- (The Journal of Cell Biology, 2000)
    We identify new organelles associated with the vacuolar system in plant cells. These organelles are defined biochemically by their internal content of three integral membrane proteins: a chimeric reporter protein that moves ...
  • The Protein Storage Vacuole: A Unique Compound Organelle 

    Jiang, Liwen; Phillips, Thomas; Hamm, Christopher A.; Drozdowicz, Yolanda M.; Rea, Philip A.; Maeshima, Masayoshi; Rogers, Sally W.; Rogers, John C., 1949- (The Journal of Cell Biology, 2001)
    Storage proteins are deposited into protein storage vacuoles (PSVs) during plant seed development and maturation and stably accumulate to high levels; subsequently, during germination the storage proteins are rapidly ...
  • Bacteriophage HP2 of Haemophilus influenzae 

    Williams, Bryan J.; Golomb, Miriam; Phillips, Thomas; Brownlee, Joshua; Olson, Maynard; Smith, Arnold L. (American Society for Microbiology, 2002)
    Temperate bacteriophages effect chromosomal evolution of their bacterial hosts, mediating rearrangements and the acquisition of novel genes from other taxa. Although the Haemophilus influenzae genome shows evidence of ...
  • Haplo-Insufficiency of MPK3 in MPK6 Mutant Background Uncovers a Novel Function of These Two MAPKs in Arabidopsis Ovule Development 

    Wang, Huachun; Liu, Yidong; Bruffet, Kristin; Lee, Justin; Hause, Gerd; Walker, John C.; Zhang, Shuqun, 1970- (American Society of Plant Biologists, 2008)
    The plant life cycle includes diploid sporophytic and haploid gametophytic generations. Female gametophytes (embryo sacs) in higher plants are embedded in specialized sporophytic structures (ovules). Here, we report that ...
  • Magnetic tweezers for intracellular applications 

    Hosu, Basarab Gabriel, 1968-; Jakab, Karoly Robert, 1974-; Banki, Peter; Toth, Ferenc I.; Forgács, Gabor, 1949- (American Institute of Physics, 2003)
    We have designed and constructed a versatile magnetic tweezer primarily for intracellular investigations. The micromanipulator uses only two coils to simultaneously magnetize to saturation micron-size superparamagnetic ...
  • Phase transformations in a model mesenchymal tissue 

    Newman, Stuart A.; Forgács, Gabor, 1949-; Hinner, Bernard; Maier, Christian W.; Sackmann, E. (Erich) (Institute of Physics, 2004)
    Connective tissues, the most abundant tissue type of the mature mammalian body, consist of cells suspended in complex microenvironments known as extracellular matrices (ECMs). In the immature connective tissues (mesenchymes) ...
  • Eukaryotic membrane tethers revisited using magnetic tweezers 

    Hosu, Basarab Gabriel, 1968-; Sun, Mingzhai, 1979-; Marga, Francoise; Grandbois, Michèle; Forgács, Gabor, 1949- (Institute of Physics, 2007)
    Membrane nanotubes, under physiological conditions, typically form en masse. We employed magnetic tweezers (MTW) to extract tethers from human brain tumor cells and compared their biophysical properties with tethers extracted ...
  • Experimental evaluation of apparent tissue surface tension based on the exact solution of the Laplace equation 

    Norotte, Cyrille, 1983-; Marga, Francoise; Neagu, Adrian; Kosztin, Ioan; Forgács, Gabor, 1949- (IOP, 2008)
    The notion of apparent tissue surface tension offered a systematic way to interpret certain morphogenetic processes in early development. It also allowed deducing quantitative information on cellular and molecular parameters ...
  • Effects of Timber Harvest on Amphibian Populations: Understanding Mechanisms from Forest Experiments 

    Semlitsch, Raymond D.; Todd, Brian D.; Blomquist, Sean M.; Calhoun, Aram J. K.; Gibbons, J. Whitfield, 1939-; Gibbs, James P.; Graeter, Gabrielle J.; Harper, Elizabeth B., 1978-; Hocking, Daniel J.; Hunter, Malcolm L., Jr.; Patrick, David A.; Rittenhouse, Tracy A. Green, 1978-; Rothermel, Betsie B. (American Institute of Biological Sciences, 2009)
    Harvesting timber is a common form of land use that has the potential to cause declines in amphibian populations. It is essential to understand the behavior and fate of individuals and the resulting consequences for vital ...
  • Effects of Timber Harvest on Amphibian Populations: Understanding Mechanisms from Forest Experiments. Appendix 

    Semlitsch, Raymond D.; Todd, Brian D.; Blomquist, Sean M.; Calhoun, Aram J. K.; Gibbons, J. Whitfield, 1939-; Gibbs, James P.; Graeter, Gabrielle J.; Harper, Elizabeth B., 1978-; Hocking, Daniel J.; Hunter, Malcolm L., Jr.; Patrick, David A.; Rittenhouse, Tracy A. Green, 1978-; Rothermel, Betsie B. (2009)
    The Appendix provides a summary of results for four forest management treatments according to region, species, and response variables.