What are the risks of using atypical antipsychotic drugs in treating patients with neuropsychiatric symptoms of dementia?
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Severe adverse outcomes, including cerebrovascular events and death, have been observed in patients with dementia who are treated with atypical antipsychotic drugs (AAPDs) for neuropsychiatric symptoms. (SOR: A, based on systematic reviews.) Other adverse effects of AAPDs in this population include somnolence, abnormal gait, urinary retention or urinary tract infections, extrapyramidal symptoms, and decline in cognitive function. (SOR: A, based on systematic reviews.)
Evidence Based Practice 15(4): 06.