What is the appropriate duration of drug interruption for patients taking dabigatran who need an invasive procedure?
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Before invasive surgery, dabigatran should be discontinued for a minimum of 24 hours in patients with a creatinine clearance >50 mL/min. This should be extended up to 5 days in patients with lower creatinine clearance and for procedures with a high bleeding risk. Because of its rapid onset of action, resumption of dabigatran postoperatively should be guided by an assessment of bleeding risk. (SOR: C, based on expert opinion and consensus guidelines.)
Evidence Based Practice 15(4): 14.