[-] Show simple item record

dc.contributor.advisorCornelison, Dawneng
dc.contributor.authorThompson, Katie Lynn Capkoviceng
dc.date.issued2011eng
dc.date.submitted2011 Summereng
dc.description"July 2011"eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 18, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Dawn Cornelisoneng
dc.descriptionVita.eng
dc.description.abstractAdult muscle stem cells or satellite cells are the committed somatic stem cells responsible for maintenance and regeneration of adult skeletal muscle tissue. Skeletal muscle is capable of multiple rounds of complete regeneration due to the action of satellite cells. These cells are necessary for the muscle to respond to multiple stimuli including, periods of growth, injury, adaptation and aging. Additionally, in severe myopathic diseases such as Duchenne Muscular Dystrophy, the regenerative capacity of skeletal muscle is exhausted. The potential of stem cells in regenerative medicine lies in the ability to remove them from their natural niche, inducing them to proliferate in culture and placing functional cells back into a tissue environment. In order to achieve this it is important to better understand the mechanisms regulating the processes of proliferation and differentiation in satellite cells. I have addressed three important topics pertaining to the study of these functions in satellite cells: how to differentiate between proliferating cells and cells that have recently committed to myogenic differentiation on the basis of their membrane raft components, specifically neural cell adhesion molecule expression, how separate domains of a single protein, syndecan-4, can regulate proliferation and differentiation, and how the interpretation of a secreted signal can regulate satellite cell proliferation as a population.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentx, 138 pageseng
dc.identifier.oclc872560400eng
dc.identifier.urihttps://doi.org/10.32469/10355/14234eng
dc.identifier.urihttps://hdl.handle.net/10355/14234
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.sourceSubmitted by University of Missouri--Columbia Graduate School.eng
dc.subjectstem celleng
dc.subjectsatellite celleng
dc.subjectsyndecaneng
dc.subjectmuscle precursor celleng
dc.subjecttranscription factoreng
dc.titleFlipping the switch : regulation of proliferation and differentiation in adult muscle stem cellseng
dc.typeThesiseng
thesis.degree.disciplineBiological sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record