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dc.contributor.advisorBeerntsen, Brenda T.eng
dc.contributor.authorRoberts, Renee Nicoleeng
dc.date.issued2011eng
dc.date.submitted2011 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 30, 2012).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Brenda Beerntseneng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Molecular microbiology & immunology.eng
dc.descriptionPh. D. University of Missouri-Columbia 2011.eng
dc.description"December 2011"eng
dc.description.abstractMalaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. In an effort to discover molecules that aid in parasite invasion, P. falciparum MAL13P1.319 (PfMAL13P1.319) was identified by a search of the Plasmodium genome database and demonstrates significant similarity with orthologs in other Plasmodium spp. and no orthologs in humans. The PfMAL13P1.319 transcript was present during the erythrocytic stages, oocyst sporozoites, and salivary gland sporozoites and protein was detected only during the late erythrocytic stages. Additional mosquito parasite stages not previously observed or reported, such as zygotes, hemolymph sporozoites, and oocyst sporozoites, also were analyzed however displayed no detection of PfMAL13P1.319. The functional role of PfMAL13P1.319 has yet to be determined, although multiple failed attempts at disrupting the gene would suggest that the PfMAL131.319 protein may have an important function for intraerythrocytic parasites. A comparative study of the P. berghei ortholog of MAL13P1.319 (PbMAL13P1.319) discovered a 2.0-kb gene predicted to encode a surface or secreted antigen and has transcript expression during the erythrocytic stages. Overall, this dissertation describes the characteristics of MAL13P1.319 in parasite biology.eng
dc.format.extentxi, 153 pageseng
dc.identifier.merlinb87209974eng
dc.identifier.oclc805564185eng
dc.identifier.otherRobertsR-120911-D348eng
dc.identifier.urihttp://hdl.handle.net/10355/14447eng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2011 Freely available dissertations (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertationseng
dc.subjectparasitic organismeng
dc.subjectdisease transmissioneng
dc.subjecterythrocytic stageseng
dc.subjectparasite biologyeng
dc.subject.lcshPlasmodium falciparum -- Geneticseng
dc.subject.lcshPlasmodium falciparum -- Microbiologyeng
dc.subject.lcshMalaria -- Genetic aspectseng
dc.subject.lcshProteinseng
dc.subject.meshPlasmodium falciparum -- geneticseng
dc.subject.meshPlasmodium falciparum -- microbiologyeng
dc.subject.meshMalaria -- geneticseng
dc.subject.meshProtozoan Proteins -- geneticseng
dc.titleInsights into understanding malaria parasite biology: characterization of the Plasmodium protein, MAL13P1.319eng
dc.typeThesiseng
thesis.degree.disciplineMolecular microbiology and immunology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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