Insights into understanding malaria parasite biology: characterization of the Plasmodium protein, MAL13P1.319

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Insights into understanding malaria parasite biology: characterization of the Plasmodium protein, MAL13P1.319

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/14447

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dc.contributor.advisor Beerntsen, Brenda T. en_US
dc.contributor.author Roberts, Renee Nicole
dc.date.accessioned 2012-05-30T17:28:27Z
dc.date.available 2012-05-30T17:28:27Z
dc.date.issued 2011
dc.date.submitted 2011 Fall en_US
dc.identifier.other RobertsR-120911-D348
dc.identifier.uri http://hdl.handle.net/10355/14447
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on May 30, 2012). en_US
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Dissertation advisor: Dr. Brenda Beerntsen en_US
dc.description Vita. en_US
dc.description Includes bibliographical references. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Molecular microbiology & immunology. en_US
dc.description Ph. D. University of Missouri-Columbia 2011. en_US
dc.description "December 2011" en_US
dc.description.abstract Malaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. In an effort to discover molecules that aid in parasite invasion, P. falciparum MAL13P1.319 (PfMAL13P1.319) was identified by a search of the Plasmodium genome database and demonstrates significant similarity with orthologs in other Plasmodium spp. and no orthologs in humans. The PfMAL13P1.319 transcript was present during the erythrocytic stages, oocyst sporozoites, and salivary gland sporozoites and protein was detected only during the late erythrocytic stages. Additional mosquito parasite stages not previously observed or reported, such as zygotes, hemolymph sporozoites, and oocyst sporozoites, also were analyzed however displayed no detection of PfMAL13P1.319. The functional role of PfMAL13P1.319 has yet to be determined, although multiple failed attempts at disrupting the gene would suggest that the PfMAL131.319 protein may have an important function for intraerythrocytic parasites. A comparative study of the P. berghei ortholog of MAL13P1.319 (PbMAL13P1.319) discovered a 2.0-kb gene predicted to encode a surface or secreted antigen and has transcript expression during the erythrocytic stages. Overall, this dissertation describes the characteristics of MAL13P1.319 in parasite biology. en_US
dc.format.extent xi, 153 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2011 Freely available dissertations (MU) en_US
dc.subject parasitic organism en_US
dc.subject disease transmission en_US
dc.subject erythrocytic stages en_US
dc.subject parasite biology en_US
dc.subject.lcsh Plasmodium falciparum -- Genetics
dc.subject.lcsh Plasmodium falciparum -- Microbiology
dc.subject.lcsh Malaria -- Genetic aspects
dc.subject.lcsh Proteins
dc.subject.mesh Plasmodium falciparum -- genetics
dc.subject.mesh Plasmodium falciparum -- microbiology
dc.subject.mesh Malaria -- genetics
dc.subject.mesh Protozoan Proteins -- genetics
dc.title Insights into understanding malaria parasite biology: characterization of the Plasmodium protein, MAL13P1.319 en_US
dc.type Thesis en_US
thesis.degree.discipline Molecular microbiology & immunology en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US
dc.identifier.merlin b87209974
dc.identifier.oclc 805564185
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertations


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