[-] Show simple item record

dc.contributor.advisorYao, Gang, Ph. D.en_US
dc.contributor.authorShuaib, Ali
dc.date.issued2011
dc.date.submitted2011 Fallen_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 30, 2012).en_US
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file.en_US
dc.descriptionDissertation advisor: Dr. Gang Yaoen_US
dc.descriptionVita.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Biological engineering.en_US
dc.descriptionPh. D. University of Missouri--Columbia 2011.en_US
dc.description"December 2011"en_US
dc.description.abstractOptical methods are promising for non-invasive tissue characterization. Biological tissues can be classified into isotropic tissues and anisotropic tissues. The optical properties of isotropic tissues such as adipose tissue are independent of measurement direction. However, optical properties of anisotropic tissues such as tendon are different along different measurement directions. We used Monte Carlo simulation to study light propagation in fibrous tissues such as tendon and cartilage. Fibrous tissues were modeled as a mixture of aligned cylinders and randomly distributed background spherical particles. Both spatial- and time-resolved reflectance measurements were simulated and compared with predictions from anisotropic diffuse theory. Optical scattering and absorption properties of fibrous tissue can be measured by numerically fitting the analytical diffuse solution to time-resolved reflectance. The results indicated that both isotropic and anisotropic diffuse theory can be applied to derive the background optical properties of fibrous tissue. The scattering properties of the fibrous component can also be also determined if the fiber size is known. Experimental studies were also conducted to study time-resolved reflectance in fibrous tissue by using a fiber optics based low-coherence Mach-Zehnder interferometer. The experimental system was validated in tissue phantoms. In tendon samples, the measured time-resolved reflectance was different at different measurement angles, which was satisfactorily explained by using the anisotropic diffuse theory. Both optical absorption and scattering properties can be derived by fitting the time-resolved isotropic diffusion solution to experimental measurements.en_US
dc.format.extentxii, 119 pagesen_US
dc.identifier.otherShuaibA-120911-D114
dc.identifier.urihttp://hdl.handle.net/10355/14451
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartofcollection2011 Freely available dissertations (MU)
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertations
dc.subjectphoton migrationen_US
dc.subjectMonte Carlo simulationen_US
dc.subjectturbid mediumen_US
dc.subjectanisotropic diffuse equationen_US
dc.titleCharacterizing optical properties in fibrous tissuesen_US
dc.typeThesisen_US
thesis.degree.disciplineBiological engineeringeng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record