Characterizing optical properties in fibrous tissues

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Characterizing optical properties in fibrous tissues

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/14451

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dc.contributor.advisor Yao, Gang, Ph. D. en_US
dc.contributor.author Shuaib, Ali
dc.date.accessioned 2012-05-30T19:21:26Z
dc.date.available 2012-05-30T19:21:26Z
dc.date.issued 2011
dc.date.submitted 2011 Fall en_US
dc.identifier.other ShuaibA-120911-D114
dc.identifier.uri http://hdl.handle.net/10355/14451
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on May 30, 2012). en_US
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract, appears in the public.pdf file. en_US
dc.description Dissertation advisor: Dr. Gang Yao en_US
dc.description Vita. en_US
dc.description Includes bibliographical references. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Biological engineering. en_US
dc.description Ph. D. University of Missouri--Columbia 2011. en_US
dc.description "December 2011" en_US
dc.description.abstract Optical methods are promising for non-invasive tissue characterization. Biological tissues can be classified into isotropic tissues and anisotropic tissues. The optical properties of isotropic tissues such as adipose tissue are independent of measurement direction. However, optical properties of anisotropic tissues such as tendon are different along different measurement directions. We used Monte Carlo simulation to study light propagation in fibrous tissues such as tendon and cartilage. Fibrous tissues were modeled as a mixture of aligned cylinders and randomly distributed background spherical particles. Both spatial- and time-resolved reflectance measurements were simulated and compared with predictions from anisotropic diffuse theory. Optical scattering and absorption properties of fibrous tissue can be measured by numerically fitting the analytical diffuse solution to time-resolved reflectance. The results indicated that both isotropic and anisotropic diffuse theory can be applied to derive the background optical properties of fibrous tissue. The scattering properties of the fibrous component can also be also determined if the fiber size is known. Experimental studies were also conducted to study time-resolved reflectance in fibrous tissue by using a fiber optics based low-coherence Mach-Zehnder interferometer. The experimental system was validated in tissue phantoms. In tendon samples, the measured time-resolved reflectance was different at different measurement angles, which was satisfactorily explained by using the anisotropic diffuse theory. Both optical absorption and scattering properties can be derived by fitting the time-resolved isotropic diffusion solution to experimental measurements. en_US
dc.format.extent xii, 119 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.subject photon migration en_US
dc.subject Monte Carlo simulation en_US
dc.subject turbid medium en_US
dc.subject anisotropic diffuse equation en_US
dc.title Characterizing optical properties in fibrous tissues en_US
dc.type Thesis en_US
thesis.degree.discipline Biological engineering en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertations
dc.relation.ispartofcollection 2011 Freely available dissertations (MU)


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