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dc.contributor.advisorZhang, Cuihuaeng
dc.contributor.authorZhang, Hanrui, 1980-eng
dc.date.issued2011eng
dc.date.submitted2011 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2012).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Cuihua Zhangeng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri-Columbia 2011.eng
dc.description"December 2011"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The prevalence of obesity and diabetes is rising dramatically worldwide. Increased adiposity is associated with elevated cardiovascular risk factors, leading us to postulate a significant role for adipose in the regulation of cardiovascular function. Our goal is to understand the role of adipose in the regulation of endothelial function, and the effects of therapeutic interventions on ameliorating endothelial dysfunction by modulating adipose-derived factors in type 2 diabetes. First, we found that TNF[alpha], an adipose-derived proinflammatory cytokine, plays a critical role in diabetes-associated endothelial dysfunction. As a natural anti-oxidant, resveratrol improves endothelial function by inhibiting TNF[alpha] and its downstream signaling. Second, adiponectin is an adipose-derived hormone. There is reciprocal regulation between adiponectin and TNF[alpha] in vasculature and adiponectin improves endothelial function. Third, as the hallmark cytokine of T-lymphocytes, IFN[lambda] stimulates adipose inflammation, adipose/vascular oxidative stress, and macrophage accumulation in the adventitia of vasculature, and impairs endothelial function. Bariatric surgery is effective in ameliorating IFN[lambda]-mediated adipose inflammation and endothelial dysfunction in type 2 diabetes. Therefore, adipose and adipose-derived factors are proposed to serve as promising therapeutic targets in the effort to manage type 2 diabetes and its vascular complications.eng
dc.format.extentxvi, 214 pageseng
dc.identifier.merlinb87210897eng
dc.identifier.oclc805705001eng
dc.identifier.urihttps://doi.org/10.32469/10355/14476eng
dc.identifier.urihttps://hdl.handle.net/10355/14476
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2011 UM restricted dissertations (MU)eng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertations.eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectdiabeteseng
dc.subjectendothelial dysfunctioneng
dc.subjectobesityeng
dc.subjectvasculopathyeng
dc.subjectoxidative stresseng
dc.subject.meshAdipose Tissue -- physiologyeng
dc.subject.meshEndothelium, Vascular -- physiopathologyeng
dc.subject.meshAdiponectin -- physiologyeng
dc.subject.meshDiabetes Mellitus, Type 2 -- complicationseng
dc.subject.meshDiabetic Angiopathies -- prevention & controleng
dc.subject.meshTumor Necrosis Factor alpha -- physiologyeng
dc.titleThe role of adipose tissue in the regulation of endothelial function in type 2 diabetes : mechanisms and therapeutic implicationseng
dc.typeThesiseng
thesis.degree.disciplinePharmacology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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