Development of long wavelength fluorescent sensors
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[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The design, synthesis and spectroscopic properties of several long wavelength/NIR fluorescent sensors are discussed. Amongst them, the metal complex-indicator sensors are developed based on the indicator-displacement-assay (IDA) strategy; the other BODIPY derived fluorescent sensors are developed based on the indicator-spacer-receptor (ISR) strategy. For the IDA sensors, one [PBA-Zn receptor + ARS] sensor showed some unique dual wavelength patterns when different sugar analytes were introduced. The [Cu complex + Acid Blue 45] sensors have NIR fluorescent properties and displayed high affinity towards various amino acids and warfarin. For the ISR BODIPY sensors, two of the pH responsive sensors have fluorescent emission at 600nm and displayed appropriate pKas for a physiological environment. One piperazine-BODIPY sensor with a novel structure showed a turn-on NIR fluorescent emission when protonated. One di-(pycolyl)amine-BODIPY sensor dispayed a turn-on NIR fluorescent emission when binding Zn2+. Brief introductions of molecular recognition and molecular sensing are also presented.
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