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dc.contributor.advisorGlass, Timothy E. (Timothy Edward)eng
dc.contributor.authorZhang, Shaohuieng
dc.date.issued2011eng
dc.date.submitted2011 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Timothy E. Glasseng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri--Columbia 2011.eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The design, synthesis and spectroscopic properties of several long wavelength/NIR fluorescent sensors are discussed. Amongst them, the metal complex-indicator sensors are developed based on the indicator-displacement-assay (IDA) strategy; the other BODIPY derived fluorescent sensors are developed based on the indicator-spacer-receptor (ISR) strategy. For the IDA sensors, one [PBA-Zn receptor + ARS] sensor showed some unique dual wavelength patterns when different sugar analytes were introduced. The [Cu complex + Acid Blue 45] sensors have NIR fluorescent properties and displayed high affinity towards various amino acids and warfarin. For the ISR BODIPY sensors, two of the pH responsive sensors have fluorescent emission at 600nm and displayed appropriate pKas for a physiological environment. One piperazine-BODIPY sensor with a novel structure showed a turn-on NIR fluorescent emission when protonated. One di-(pycolyl)amine-BODIPY sensor dispayed a turn-on NIR fluorescent emission when binding Zn2+. Brief introductions of molecular recognition and molecular sensing are also presented.eng
dc.format.extentxv, 161 pageseng
dc.identifier.oclc872562640eng
dc.identifier.urihttps://doi.org/10.32469/10355/14477eng
dc.identifier.urihttps://hdl.handle.net/10355/14477
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectfluorophoreeng
dc.subjectindicator displacementeng
dc.subjectdual wavelength patterneng
dc.subjectfluorescent sensoreng
dc.titleDevelopment of long wavelength fluorescent sensorseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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