Molecular genetic studies of canine inherited diseases

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Molecular genetic studies of canine inherited diseases

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/14514

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Title: Molecular genetic studies of canine inherited diseases
Author: Farias, Fabiana Helena Geraldo
Keywords: gene mapping
comparative genetics
gene-causing diseases
domestic dog
Date: 2011
Publisher: University of Missouri-Columbia
Abstract: The domestic dog has advantageous genome information ideal for mapping genes that cause disease. Humans share many diseases with dogs, which makes dogs an ideal model for studying the comparative genetics of disease. The availability of a canine genome reference sequence and high density SNP chips has facilitated the study of inherited diseases in dogs. The identification of gene-causing diseases in dogs is of relevance for human health. Here we describe the identification of causative mutations for three different canine diseases in orthologs of genes associated with orthologous human diseases. Among these, we describe what may prove to be the first inherited canine disease to be identified by whole genome sequencing. We discuss the importance of these finding and suggest future studies for each project.
URI: http://hdl.handle.net/10355/14514
Other Identifiers: FariasF-120211-D297
Rights: Access is limited to the campus of the University of Missouri-Columbia.

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