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dc.contributor.advisorJohnson, Gary S.eng
dc.contributor.authorFarias, Fabiana Helena Geraldoeng
dc.date.issued2011eng
dc.date.submitted2011 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on June 5, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Gary S. Johnsoneng
dc.descriptionVita.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionPh. D. University of Missouri--Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Genetics area program.eng
dc.description"December 2011"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The domestic dog has advantageous genome information ideal for mapping genes that cause disease. Humans share many diseases with dogs, which makes dogs an ideal model for studying the comparative genetics of disease. The availability of a canine genome reference sequence and high density SNP chips has facilitated the study of inherited diseases in dogs. The identification of gene-causing diseases in dogs is of relevance for human health. Here we describe the identification of causative mutations for three different canine diseases in orthologs of genes associated with orthologous human diseases. Among these, we describe what may prove to be the first inherited canine disease to be identified by whole genome sequencing. We discuss the importance of these finding and suggest future studies for each project.eng
dc.format.extentviii, 96 pageseng
dc.identifier.oclc872562221eng
dc.identifier.urihttps://hdl.handle.net/10355/14514
dc.identifier.urihttps://doi.org/10.32469/10355/14514eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campus of the University of Missouri--Columbia.eng
dc.subjectgene mapping ; comparative genetics ; gene-causing diseases ; domestic dogeng
dc.titleMolecular genetic studies of canine inherited diseaseseng
dc.typeThesiseng
thesis.degree.disciplineGenetic Area Program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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