dc.contributor.advisor | Johnson, Gary S. | eng |
dc.contributor.author | Farias, Fabiana Helena Geraldo | eng |
dc.date.issued | 2011 | eng |
dc.date.submitted | 2011 Fall | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on June 5, 2012). | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. | eng |
dc.description | Dissertation advisor: Dr. Gary S. Johnson | eng |
dc.description | Vita. | eng |
dc.description | Includes bibliographical references. | eng |
dc.description | Ph. D. University of Missouri--Columbia 2011. | eng |
dc.description | "December 2011" | eng |
dc.description.abstract | [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The domestic dog has advantageous genome information ideal for mapping genes that cause disease. Humans share many diseases with dogs, which makes dogs an ideal model for studying the comparative genetics of disease. The availability of a canine genome reference sequence and high density SNP chips has facilitated the study of inherited diseases in dogs. The identification of gene-causing diseases in dogs is of relevance for human health. Here we describe the identification of causative mutations for three different canine diseases in orthologs of genes associated with orthologous human diseases. Among these, we describe what may prove to be the first inherited canine disease to be identified by whole genome sequencing. We discuss the importance of these finding and suggest future studies for each project. | eng |
dc.format.extent | viii, 96 pages | eng |
dc.identifier.oclc | 872562221 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/14514 | |
dc.identifier.uri | https://doi.org/10.32469/10355/14514 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | Access is limited to the campus of the University of Missouri--Columbia. | eng |
dc.subject | gene mapping ; comparative genetics ; gene-causing diseases ; domestic dog | eng |
dc.title | Molecular genetic studies of canine inherited diseases | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Genetic area program (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |