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    Cytauxzoon felis : an emerging feline pathogen and potential therapy

    Lewis, Kristin.
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    [PDF] research.pdf (952.3Kb)
    [PDF] short.pdf (81.42Kb)
    Date
    2011
    Format
    Thesis
    Metadata
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    Abstract
    Cytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as domestic cats at an Arkansas cat sanctuary. Amplicon characterization suggests cats were infected at the sanctuary with a North American strain. Using naturally infected carrier domestic queens, we demonstrated that unlike other hemoprotozoa such as closely related Theileria species, perinatal transmission of C. felis is unlikely to be an important source of infection. Additionally, after determining basic pharmacokinetics of the antiprotozoal drug diminazene in healthy, purpose bred cats, we assessed the ability of the drug to eliminate the parasite from naturally infected cats using either a low dose (3 mg/kg twice, 1 week apart) or a high dose (4 mg/kg daily for 5 days). Neither dose eliminated parasitemia, but adverse reactions were commonly observed.
    URI
    https://hdl.handle.net/10355/14553
    https://doi.org/10.32469/10355/14553
    Degree
    M.S.
    Thesis Department
    Veterinary biomedical sciences (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • Biomedical Sciences electronic theses and dissertations (MU)
    • 2011 MU theses - Freely available online

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