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dc.contributor.advisorCohn, Leah A.eng
dc.contributor.authorLewis, Kristin.eng
dc.date.issued2011eng
dc.date.submitted2011 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on June 7, 2012).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Leah Cohneng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri-Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description"Dec 2011"eng
dc.description.abstractCytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as domestic cats at an Arkansas cat sanctuary. Amplicon characterization suggests cats were infected at the sanctuary with a North American strain. Using naturally infected carrier domestic queens, we demonstrated that unlike other hemoprotozoa such as closely related Theileria species, perinatal transmission of C. felis is unlikely to be an important source of infection. Additionally, after determining basic pharmacokinetics of the antiprotozoal drug diminazene in healthy, purpose bred cats, we assessed the ability of the drug to eliminate the parasite from naturally infected cats using either a low dose (3 mg/kg twice, 1 week apart) or a high dose (4 mg/kg daily for 5 days). Neither dose eliminated parasitemia, but adverse reactions were commonly observed.eng
dc.format.extentix, 117 pageseng
dc.identifier.merlinb87209950eng
dc.identifier.oclc805564155eng
dc.identifier.otherLewisK-121211-T400eng
dc.identifier.urihttp://hdl.handle.net/10355/14553eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2011 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011 Theseseng
dc.subjectbobcat fevereng
dc.subjectparasitic organismeng
dc.subjectdiminazeneeng
dc.subject.lcshApicomplexaeng
dc.subject.lcshCats -- Parasiteseng
dc.subject.lcshAntiprotozoal agentseng
dc.titleCytauxzoon felis: an emerging feline pathogen and potential therapyeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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