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dc.contributor.advisorCohn, Leah A.en_US
dc.contributor.authorLewis, Kristin.
dc.date.issued2011
dc.date.submitted2011 Fallen_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on June 7, 2012).en_US
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionThesis advisor: Dr. Leah Cohnen_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionM.S. University of Missouri-Columbia 2011.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.en_US
dc.description"Dec 2011"en_US
dc.description.abstractCytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as domestic cats at an Arkansas cat sanctuary. Amplicon characterization suggests cats were infected at the sanctuary with a North American strain. Using naturally infected carrier domestic queens, we demonstrated that unlike other hemoprotozoa such as closely related Theileria species, perinatal transmission of C. felis is unlikely to be an important source of infection. Additionally, after determining basic pharmacokinetics of the antiprotozoal drug diminazene in healthy, purpose bred cats, we assessed the ability of the drug to eliminate the parasite from naturally infected cats using either a low dose (3 mg/kg twice, 1 week apart) or a high dose (4 mg/kg daily for 5 days). Neither dose eliminated parasitemia, but adverse reactions were commonly observed.en_US
dc.format.extentix, 117 pagesen_US
dc.identifier.merlinb87209950
dc.identifier.oclc805564155
dc.identifier.otherLewisK-121211-T400
dc.identifier.urihttp://hdl.handle.net/10355/14553
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2011 Freely available theses (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011 Theses
dc.subjectbobcat feveren_US
dc.subjectparasitic organismen_US
dc.subjectdiminazeneen_US
dc.subject.lcshApicomplexa
dc.subject.lcshCats -- Parasites
dc.subject.lcshAntiprotozoal agents
dc.titleCytauxzoon felis: an emerging feline pathogen and potential therapyen_US
dc.typeThesisen_US
thesis.degree.disciplineVeterinary biomedical sciencesen_US
thesis.degree.disciplineVeterinary biomedical scienceseng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelMastersen_US
thesis.degree.nameM.S.en_US


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