Cytauxzoon felis: an emerging feline pathogen and potential therapy

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Cytauxzoon felis: an emerging feline pathogen and potential therapy

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/14553

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dc.contributor.advisor Cohn, Leah A. en_US
dc.contributor.author Lewis, Kristin.
dc.date.accessioned 2012-06-07T14:21:06Z
dc.date.available 2012-06-07T14:21:06Z
dc.date.issued 2011
dc.date.submitted 2011 Fall en_US
dc.identifier.other LewisK-121211-T400
dc.identifier.uri http://hdl.handle.net/10355/14553
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on June 7, 2012). en_US
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Thesis advisor: Dr. Leah Cohn en_US
dc.description Includes bibliographical references. en_US
dc.description M.S. University of Missouri-Columbia 2011. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences. en_US
dc.description "Dec 2011" en_US
dc.description.abstract Cytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as domestic cats at an Arkansas cat sanctuary. Amplicon characterization suggests cats were infected at the sanctuary with a North American strain. Using naturally infected carrier domestic queens, we demonstrated that unlike other hemoprotozoa such as closely related Theileria species, perinatal transmission of C. felis is unlikely to be an important source of infection. Additionally, after determining basic pharmacokinetics of the antiprotozoal drug diminazene in healthy, purpose bred cats, we assessed the ability of the drug to eliminate the parasite from naturally infected cats using either a low dose (3 mg/kg twice, 1 week apart) or a high dose (4 mg/kg daily for 5 days). Neither dose eliminated parasitemia, but adverse reactions were commonly observed. en_US
dc.format.extent ix, 117 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2011 Freely available theses (MU) en_US
dc.subject bobcat fever en_US
dc.subject parasitic organism en_US
dc.subject diminazene en_US
dc.subject.lcsh Apicomplexa
dc.subject.lcsh Cats -- Parasites
dc.subject.lcsh Antiprotozoal agents
dc.title Cytauxzoon felis: an emerging feline pathogen and potential therapy en_US
dc.type Thesis en_US
thesis.degree.discipline Veterinary biomedical sciences en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name M.S. en_US
thesis.degree.level Masters en_US
dc.identifier.merlin b87209950
dc.identifier.oclc 805564155
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011 Theses


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