What are the benefits of treating subclinical hypothyroidism?
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Although thyroxine replacement in subclinical hypothyroidism (SCH) has been shown to improve lipids, renal function, blood pressure, and diastolic function (SOR: C, based on studies with disease-oriented outcomes), there is no evidence that treatment improves cognitive function, mood, or quality of life (SOR: A, based on a meta-analysis). There is evidence of an increased risk of hip fracture among men with SCH; but again, it is unknown if treatment is beneficial. (SOR: B, based on an individual cohort study.)
Evidence Based Practice 15(5): 08-09.