How safe and effective are progestogens (progesterone or synthetic progestins) for premenstrual syndrome (PMS)?
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Oral micronized progesterone given on a daily basis and synthetic progestin given for at least 21 days per month are effective for PMS, but neither agent is effective when given only during the luteal phase. Progesterone suppositories and pessaries used on a continuous basis or during the luteal phase are not effective for PMS. (SOR: A, based on systematic review of RCTs.) Insufficient evidence exists to evaluate the safety of progesterone or progestins for PMS.
Evidence Based Practice 15(5): 14.