Is melatonin effective for prevention or treatment of jet lag?
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Melatonin reduces jet lag symptoms in adults. (SOR: A, based on a systematic review of RCTs.) Appropriate dosing is 0.5 to 5 mg of immediate-release melatonin taken at bedtime on the first day of travel and nightly thereafter for up to 6 days. (SOR: A, based on a systematic review and evidence-based guideline.)
Evidence Based Practice 15(6): 14.