Treatment of motion sickness
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Scopolamine should be used to reduce nausea associated with motion sickness, but it does not reduce vomiting. (Strength of Recommendation [SOR]: A, based on multiple randomized controlled trials [RCTs].) Firstgeneration antihistamines (dimenhydrinate and chlorpheniramine) can also be used to reduce nausea associated with motion sickness. (SOR: B, based on multiple RCTs.) Scopolamine is more effective than meclizine (Antivert) and as effective as dimenhydrinate. Ondansetron (Zofran) and the second-generation antihistamines cetirizine (Zyrtec) and fexofenadine (Allegra) do not reduce symptoms of motion sickness and should not be used. (SOR: B, based on small RCTs.) Ginger can be used to reduce symptoms of motion sickness. (SOR: B, based on RCTs with conflicting results.)
American Family Physician 86(2) 2012.