Does St. John's wort treat depression in adult patients?
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In treating patients with major depressive disorder (MDD), St. John's wort (Hypericum perforatum) is as effective as standard antidepressants and often better tolerated. (SOR: A, based on a meta-analysis.) Clinically, St. John's wort may be considered for use in treating mild to moderate MDD. (SOR: B, based on an evidence-based guideline.)
Evidence Based Practice 15(7): 11.