Should we give anti-D immunoglobulin to Rh-negative women with first trimester bleeding?
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Little solid evidence exists for or against the use of anti-D immunoglobulin (RhIG) in women with first trimester bleeding who have a viable intrauterine pregnancy. Both the benefits of administering RhIG (a theoretical reduction of alloimmunization) and potential harms (other than the known cost) are likely small. Guidelines conflict on their recommendations.
Evidence Based Practice 15(8): 05.