Does prolonged acne treatment of adolescents with tetracycline or tretinoin have any long-term sequelae?
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These agents may be used safely in most patients. Topical tretinoin has minimal systemic absorption and has not been shown to be teratogenic. (SOR: C, extrapolated from a cohort study of adolescents and adults.) Oral tetracycline (but not doxycycline) is associated with a 0.5% incidence of hepatotoxicity. (SOR: C, extrapolated from a mixed-age case-control trial.) Also, tetracycline-class agents cause permanent staining of developing teeth and are contraindicated in pregnant adolescents. (SOR: C, based on case reports and expert opinion.)
Evidence Based Practice 15(8): 14.