[-] Show simple item record

dc.contributor.advisorSong, Qishengeng
dc.contributor.authorWang, Qianeng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on August 23, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Qisheng Song.eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri--Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Plant, insect and microbial sciences.eng
dc.description"May, 2011"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bursicon is a heterodimeric neurohormone which binds to the receptor LGR2 and regulates various aspects in cuticle sclerotization and wing expansion in diverse insect orders. However, it is still unknown why some neurosecretory cells store only one bursicon subunit, similarly, it is not fully understood the function of burs α or burs β in the course of insect development. We found that each of bursicon subunit is sufficient to induce immune responses in Drosophila larvae. The expression of several antimicrobial peptide (AMP) genes is mediated by the bursicon induced proteolytic activation of NF-кB transcription factor Relish. These results implicate the D. melanogaster neurohormone bursicon with the novel function of modulating innate immune response. They also partially explain the presence and function of a single bursicon subunit during immature stages of Drosophila. More generally, our data suggest that bursicon plays a similar role in the post-edysial periods of other insect species.eng
dc.format.extentix, 82 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/14900
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollection2011 UM restricted theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011 Theseseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjectimmune responseeng
dc.subjectlarval developmenteng
dc.subjectbursiconeng
dc.titleBuriscon regulated immune response in Drosophila melanogastereng
dc.typeThesiseng
thesis.degree.disciplinePlant, insect and microbial sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record