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dc.contributor.advisorHenry, Carolyn J.eng
dc.contributor.authorBommarito, Davideng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on August 27, 2012).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionThesis advisor: Dr. Carolyn Henryeng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionM.S. University of Missouri-Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description"May 2011"eng
dc.description.abstractIntroduction: Tavocept is a novel chemoprotector/ sensitizer that has been used in combination with cisplatin to treat adenocarcinomas. The objectives of this study were to evaluate the interaction of radiation and Tavocept on a nasal tumor cell line and try to apply the concepts to the treatment canine nasal tumors. Materials and Methods: Using cell culture techniques and the nasal carcinoma cell line RPMI 2650, various combinations of radiation, cisplatin chemotherapy, and Tavocept were evaluated. Cytotoxicity to the cells was established using the sulfarhodamine (SRB) dye assay. Results: Tavocept alone did not show any cytotoxicity or increased cell growth compared to the control group. The addition of Tavocept increased the cytotoxicity of cisplatin compared to cisplatin alone. The combination of Tavocept to radiation therapy appeared no different than radiation alone. The addition of Tavocept at a low and high concentration to radiation and cisplatin increased cytotoxicity compared to radiation and cisplatin alone. Conclusions: Tavocept by itself appears to not have any toxic effects on the cell line, but it increases the cytotoxicity of cisplatin suggesting chemosensitization. There was no apparent interaction with radiation, neither sensitization nor protection.eng
dc.format.extentvi, 73 pageseng
dc.identifier.urihttp://hdl.handle.net/10355/14956
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartof2011 Freely available theses (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Theses. 2011 Theseseng
dc.subjectnasal tumorseng
dc.subjectadenocarcinomaeng
dc.subjectcisplatineng
dc.subjectmesnaeng
dc.titleTavocept (BNP7787): a novel chemoprotector/sensitizer and radioprotector/sensitizereng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelMasterseng
thesis.degree.nameM.S.eng


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