Giant atypical carcinoid of the liver with vascular metastases and local sinusoidal invasion: a case report

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Giant atypical carcinoid of the liver with vascular metastases and local sinusoidal invasion: a case report

Please use this identifier to cite or link to this item: http://dx.doi.org/10.1186/1752-1947-1-47

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dc.contributor.author Lingamfelter, Daniel
dc.contributor.author Hoffman, Laura
dc.contributor.author Verma, Amit
dc.contributor.author DePond, William
dc.contributor.author Lankachandra, Kamani
dc.date.accessioned 2012-08-29T15:27:17Z
dc.date.available 2012-08-29T15:27:17Z
dc.date.issued 2007-07-12
dc.identifier.citation Journal of Medical Case Reports. 2007 Jul 12;1(1):47
dc.identifier.uri http://dx.doi.org/10.1186/1752-1947-1-47
dc.identifier.uri http://hdl.handle.net/10355/15043
dc.description.abstract Abstract We present the case of a 46 year old woman with a giant, 23-centimeter, atypical carcinoid of the liver. A primary site for this neoplasm could not be identified despite multiple radiographic imaging studies, including a somatostatin scan, and a thorough inspection of the bowel during surgical resection of the lesion. Histologically, the tumor displayed mild cytologic atypia, abundant necrosis, and intravascular metastases, the last feature of which was identified by immunohistochemical markers for chromogranin and synaptophysin. Also described is the unusual sinusoidal infiltration, or "spillage," of tumor cells into the surrounding liver parenchyma, a feature that has not been described as far as we are aware but may suggest an aggressive clinical course. Even though an exact definition of atypia for these lesions apparently does not exist at this point, the multiple atypical features in this case strongly suggest the diagnosis of atypical carcinoid of the liver, thus far an altogether rare and vaguely reported entity. As more cases arise in the medical literature, it may be worthwhile to establish a set of guidelines to define atypical hepatic carcinoids and other gastrointestinal carcinoids, although survivorship data thus far indicates no significant difference in the prognosis between typical versus atypical variants.
dc.title Giant atypical carcinoid of the liver with vascular metastases and local sinusoidal invasion: a case report
dc.type Journal Article
dc.date.updated 2012-08-29T15:27:17Z
dc.description.version Peer Reviewed
dc.language.rfc3066 en
dc.rights.holder Daniel Lingamfelter et al.; licensee BioMed Central Ltd.


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