Does levothyroxine supplementation reduce subjective symptoms in patients with subclinical hypothyroidism?
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Levothyroxine (LT4) supplementation does not improve hypothyroid symptoms (paresthesias, constipation, memory loss, dry skin), mood, or quality of life in adult patients with subclinical hypothyroidism (SOR: A, a systematic review). There may be a small benefit of LT4 therapy on tiredness (SOR: B, a single lower quality RCT).
Evidence Based Practice 15(9): 09.