What is the best treatment for restlessness in terminally ill patients?
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Initial management of terminal restlessness is correcting reversible causes, followed by nonpharmacologic adjuncts (SOR: C, expert opinion). Haloperidol and chlorpromazine are first-line pharmacologic agents for delirium, while benzodiazepines may be helpful with refractory agitation and when sedation is desired (SOR: B, systematic reviews of low-quality studies).
Evidence Based Practice 15(9): 14.