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dc.contributor.authorBecker, Haley V.eng
dc.contributor.authorSchneider, Rebecca I.eng
dc.contributor.authorDellsperger, Kevin C.eng
dc.contributor.authorSauer, Jameseng
dc.contributor.authorDeMarco, Vincent G.eng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2007 : University of Missouri--Columbia)eng
dc.date2007eng
dc.date.issued2007eng
dc.descriptionAbstract only availableeng
dc.description.abstractPulmonary hypertension (PH), a rapidly progressive disease, is characterized by vasoconstriction, vascular remodeling, and right ventricular hypertrophy, leading to right ventricular failure and ultimately death. It is well known that locally increased production of angiotensin-II (ANG II) increases vasoconstriction, mitogenesis, fibrosis, inflammation and thrombosis during hypertension. Renin, a precursor enzyme in ANG II production, acts on the peptide angiotensinogin to form angiotensin-I (ANG I). ANG I is cleaved by angiotensin converting enzyme (ACE) to form ANG II. The Ren-2 rat is a transgenic strain that overexpresses mouse renin in a number of tissues. We recently determined that the Ren-2 rat exhibits PH, presumably as a consequence of transgene expression in the lungs, which could lead to elevated levels of ANG II in the lung. Overexpression of ACE in the intra-acinar arteries of patients with PH supports the hypothesis that locally increased production of ANG II leads to PH. We hypothesize that mouse renin will be expressed in the lung vasculature of Ren-2 rats, specifically in endothelial and smooth muscle cells. Confirmation of this hypothesis would support the presence of the mouse renin transgene in the Ren-2 rat and suggests the presence of a local RAS in the lungs.eng
dc.description.sponsorshipLife Sciences Undergraduate Research Opportunity Programeng
dc.identifier.urihttp://hdl.handle.net/10355/1559eng
dc.languageen_USeng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=eng
dc.subjectpulmonary hypertension (PH)eng
dc.subjectangiotensinogineng
dc.subjecttransgene expressioneng
dc.titleLung tissue expression of renin in ren-2 rats [abstract]eng
dc.typePresentationeng


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