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    Evaluation of elevated serum transaminase levels

    Grover, Michael
    Rutkowski, Richard
    Nashelsky, Joan
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    [PDF] EvaluationElevatedSerumTransaminase.pdf (149.1Kb)
    Date
    2012
    Format
    Article
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    Abstract
    The evaluation of patients with elevated transaminase levels should be individualized based on the presence of symptoms or physical examination findings that suggest serious disease or hepatic decompensation. (Strength of Recommendation [SOR]: C, expert opinion.) The initial evaluation should determine specific etiologies, such as exposure to alcohol or hepatotoxic medications, viral hepatitis, or hemochromatosis. In patients with reassuring initial test results, lifestyle modification can reverse presumed nonalcoholic fatty liver disease (NAFLD), the most common cause of persistently elevated liver transaminase levels. (SOR: B, based on cohort trials.) Transaminase levels that are elevated for longer than six months warrant additional investigation, which may include ultrasonography, additional serology, and possible liver biopsy. (SOR: C, expert opinion.)
    URI
    http://hdl.handle.net/10355/15739
    Part of
    American family physician, 86, no. 08 (October 2012)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
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