How effective are leukotriene inhibitors in children with asthma?
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Leukotriene inhibitors are more effective than placebo in reducing respiratory symptoms in children with intermittent and mild to moderate persistent asthma (SOR: B, several RCTs). They do not appear helpful in children with intermittent asthma who present with severe symptoms (SOR: B, a single RCT). Also, inhaled corticosteroids (ICS) are more effective than montelukast in preventing asthma exacerbations that require systemic corticosteroids (SOR: A, a meta-analysis in adolescents).
Evidence Based Practice 15(10): 10-11.