In patients with cytologic abnormalities on Pap smear, what are the indications for HPV DNA testing?
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Screening for high-risk human papilloma virus (HPV) can be helpful in addition to cytology in women age >30, for triage in women age >20 with atypical squamous cells of undetermined significance (ASCUS), and for follow-up of a negative colposcopy in women with atypical squamous cells-cannot rule out high grade (ASC-H) (SOR: A, RCTs and evidence-based guidelines). HPV testing in ASCUS increases the detection of cervical intraepithelial neoplasia (CIN) 2 and 3 (SOR: B, prospective case-control study).
Evidence-based practice 15, no. 10 (2012): 05-06