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dc.contributor.advisorThyfault, John P.eng
dc.contributor.authorMikus, Catherine R.eng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on October 24, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. John P. Thyfaulteng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Exercise physiology.eng
dc.description"May 2011"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The vasodilatory effects of insulin typically account for up to 40% of insulin-mediated glucose disposal; however, insulin-stimulated vasodilation is impaired in individuals with type 2 diabetes, limiting perfusion and delivery of glucose and insulin to target tissues. We have previously demonstrated that exercise prevents insulin resistance and the associated derangements in insulin-stimulated vasodilation in microvessels of rats prone to obesity and diabetes. Here, we describe new evidence indicating that exercise also reverses these derangements. The beneficial effect of exercise on vascular insulin action was consistent across studies of conduit artery blood flow in vivo and microvascular reactivity to insulin in vitro, in both humans and rodents, in response to both short-term and chronic exercise training, and were consistently associated with improvements in indices of glycemic control. Collectively, these data provide strong evidence that exercise is a powerful mediator of the metabolic and vascular effects of insulin.eng
dc.format.extentxiii, 169 pageseng
dc.identifier.oclc872569717eng
dc.identifier.urihttps://hdl.handle.net/10355/15842
dc.identifier.urihttps://doi.org/10.32469/10355/15842eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri-Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.subjecttype 2 diabeteseng
dc.subjectvascular functioneng
dc.subjectendotheliumeng
dc.subjectphysical activityeng
dc.titleOptimizing vascular and metabolic responses to insulin in type 2 diabetes: exercise as treatmenteng
dc.typeThesiseng
thesis.degree.disciplineExercise physiology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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