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dc.contributor.advisorCook, James L. (James Lee), 1965-eng
dc.contributor.authorJayabalan, Prakash S., 1980-eng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on October 25, 2012).eng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionDissertation advisor: James L. Cookeng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia, 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary pathobiology area program.eng
dc.description"May 2011"eng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage cells encapsulated in a hydrated matrix and an underlying layer comprising a stiffer, porous material to provide mechanical support and integration into the subchondral bone. Bioactive glasses (BG) are bioresorbable materials that have been shown to be osteoinductive and ostoeconductive. They have been put forward as a candidate for the bone layer of tissue engineered OC grafts. This work investigates the use of this material in this application in vivo, and then further elucidates its effect in this application by optimizing its use in vitro prior to implantation. Then we examined the effect of the type of media on the resorption of the scaffold and finally investigated the temporal effects of BG 13-93 as a culture media supplement. Our work showed that BG 13-93 may not be suitable as a bone layer for OC constructs but may instead be useful as a culture media supplement for cartilage tissue engineering purposes.eng
dc.format.extentxiii, 148 pageseng
dc.identifier.merlinb93921202eng
dc.identifier.oclc816702915eng
dc.identifier.urihttps://hdl.handle.net/10355/15853
dc.identifier.urihttps://doi.org/10.32469/10355/15853eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campus of the University of Missouri--Columbia.eng
dc.subjectosteoarthritiseng
dc.subjecttissue engineeringeng
dc.subjectbioactive glasseng
dc.subjectculture media supplementeng
dc.subjectosteochondral grafteng
dc.subject.lcshTissue engineering -- Methodologyeng
dc.subject.lcshBioactive compoundseng
dc.subject.lcshGlasseng
dc.subject.lcshTissue scaffoldseng
dc.subject.lcshCartilage cellseng
dc.subject.lcshCulture media (Biology)eng
dc.subject.meshTissue Engineering -- methodseng
dc.subject.meshGlasseng
dc.subject.meshTissue Scaffoldseng
dc.subject.meshChondrocyteseng
dc.subject.meshCulture Mediaeng
dc.titleThe evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilageeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary pathobiology area program (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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