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dc.contributor.advisorEl-Gizawy, A. Sherif (Ahmed Sherif), 1945-en_US
dc.contributor.authorArnone, Joshua
dc.contributor.otherUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertationsen_US
dc.date.issued2011
dc.date.submitted2011 Springen_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on November 6, 2012).en_US
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.en_US
dc.descriptionDissertation advisor: Dr. A. Sherif El-Gizawyen_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionVita.en_US
dc.descriptionPh. D. University of Missouri--Columbia 2011.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Mechanical and aerospace engineering.en_US
dc.description"May 2011"en_US
dc.description.abstractInternal fixation implants are widely used by orthopaedic surgeons to stabilize various types of fractures in injured patients. However, the irregular geometry of the human skeletal system, as well as the significant variation in the size and shape of bones among the population, pose great challenges in efficiently and effectively designing such devices. As a result, the need for improvement in regard to performance and fit is evident in many current internal fixation implants, particularly for high load-bearing regions such as the femur. For this reason, a comprehensive methodology was developed to design and optimize implants with maximal structural integrity and contour fitting among the population, while minimizing its influence on human biomechanics. The systematic methodology uniquely employs both new and existing techniques in medical imaging analysis, non-linear finite element methods, and optimization to obtain optimal designs prior to experimental testing. Its efficacy was demonstrated using two case studies involving the design of internal fixation implants used to stabilize various femoral shaft fractures: intramedullary nailing and locking plate systems. Comparison of finite element results - from simulated physiological loading conditions and loads induced by “virtual surgery” - among the optimized implants and those currently used in the operating room showed much improvement in regard to reliability, fit, and alteration of natural biomechanics. Subsequent experimental testing verified that the results predicted by the developed simulation-based methodology represented actual physiological scenarios within acceptable percent error and were valid for design purposes.en_US
dc.format.extentxvii, 200 pagesen_US
dc.identifier.otherArnoneJ
dc.identifier.urihttp://hdl.handle.net/10355/15993
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2011 Freely available dissertations (MU)en_US
dc.subjectbiomechanicsen_US
dc.subjectinternal fixation implanten_US
dc.subjectstructural integrityen_US
dc.titleA comprehensive simulation-based methodology for the design and optimization of orthopaedic internal fixation implantsen_US
dc.typeThesisen_US
thesis.degree.disciplineMechanical and aerospace engineeringen_US
thesis.degree.disciplineMechanical and aerospace engineeringeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


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