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dc.contributor.advisorEl-Gizawy, A. Sherif (Ahmed Sherif), 1945-eng
dc.contributor.authorArnone, Joshuaeng
dc.date.issued2011eng
dc.date.submitted2011 Springeng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on November 6, 2012).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. A. Sherif El-Gizawyeng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2011.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Mechanical and aerospace engineering.eng
dc.description"May 2011"eng
dc.description.abstractInternal fixation implants are widely used by orthopaedic surgeons to stabilize various types of fractures in injured patients. However, the irregular geometry of the human skeletal system, as well as the significant variation in the size and shape of bones among the population, pose great challenges in efficiently and effectively designing such devices. As a result, the need for improvement in regard to performance and fit is evident in many current internal fixation implants, particularly for high load-bearing regions such as the femur. For this reason, a comprehensive methodology was developed to design and optimize implants with maximal structural integrity and contour fitting among the population, while minimizing its influence on human biomechanics. The systematic methodology uniquely employs both new and existing techniques in medical imaging analysis, non-linear finite element methods, and optimization to obtain optimal designs prior to experimental testing. Its efficacy was demonstrated using two case studies involving the design of internal fixation implants used to stabilize various femoral shaft fractures: intramedullary nailing and locking plate systems. Comparison of finite element results - from simulated physiological loading conditions and loads induced by “virtual surgery” - among the optimized implants and those currently used in the operating room showed much improvement in regard to reliability, fit, and alteration of natural biomechanics. Subsequent experimental testing verified that the results predicted by the developed simulation-based methodology represented actual physiological scenarios within acceptable percent error and were valid for design purposes.eng
dc.format.extentxvii, 200 pageseng
dc.identifier.oclc872560117eng
dc.identifier.otherArnoneJeng
dc.identifier.urihttp://hdl.handle.net/10355/15993eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertations.eng
dc.subjectbiomechanicseng
dc.subjectinternal fixation implanteng
dc.subjectstructural integrityeng
dc.titleA comprehensive simulation-based methodology for the design and optimization of orthopaedic internal fixation implantseng
dc.typeThesiseng
thesis.degree.disciplineMechanical and aerospace engineering (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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