A comprehensive simulation-based methodology for the design and optimization of orthopaedic internal fixation implants

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A comprehensive simulation-based methodology for the design and optimization of orthopaedic internal fixation implants

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/15993

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dc.contributor.advisor El-Gizawy, A. Sherif (Ahmed Sherif), 1945- en_US
dc.contributor.author Arnone, Joshua
dc.contributor.other University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2011 Dissertations en_US
dc.date.accessioned 2012-11-06T20:50:21Z
dc.date.available 2012-11-06T20:50:21Z
dc.date.issued 2011
dc.date.submitted 2011 Spring en_US
dc.identifier.other ArnoneJ
dc.identifier.uri http://hdl.handle.net/10355/15993
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on November 6, 2012). en_US
dc.description The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. en_US
dc.description Dissertation advisor: Dr. A. Sherif El-Gizawy en_US
dc.description Includes bibliographical references. en_US
dc.description Vita. en_US
dc.description Ph. D. University of Missouri--Columbia 2011. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Mechanical and aerospace engineering. en_US
dc.description "May 2011" en_US
dc.description.abstract Internal fixation implants are widely used by orthopaedic surgeons to stabilize various types of fractures in injured patients. However, the irregular geometry of the human skeletal system, as well as the significant variation in the size and shape of bones among the population, pose great challenges in efficiently and effectively designing such devices. As a result, the need for improvement in regard to performance and fit is evident in many current internal fixation implants, particularly for high load-bearing regions such as the femur. For this reason, a comprehensive methodology was developed to design and optimize implants with maximal structural integrity and contour fitting among the population, while minimizing its influence on human biomechanics. The systematic methodology uniquely employs both new and existing techniques in medical imaging analysis, non-linear finite element methods, and optimization to obtain optimal designs prior to experimental testing. Its efficacy was demonstrated using two case studies involving the design of internal fixation implants used to stabilize various femoral shaft fractures: intramedullary nailing and locking plate systems. Comparison of finite element results - from simulated physiological loading conditions and loads induced by “virtual surgery” - among the optimized implants and those currently used in the operating room showed much improvement in regard to reliability, fit, and alteration of natural biomechanics. Subsequent experimental testing verified that the results predicted by the developed simulation-based methodology represented actual physiological scenarios within acceptable percent error and were valid for design purposes. en_US
dc.format.extent xvii, 200 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2011 Freely available dissertations (MU) en_US
dc.subject biomechanics en_US
dc.subject internal fixation implant en_US
dc.subject structural integrity en_US
dc.title A comprehensive simulation-based methodology for the design and optimization of orthopaedic internal fixation implants en_US
dc.type Thesis en_US
thesis.degree.discipline Mechanical and aerospace engineering en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US


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