New fluorescent chemosensors for detecting lipids

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New fluorescent chemosensors for detecting lipids

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/15998

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Title: New fluorescent chemosensors for detecting lipids
Author: Lee, Jae Seung
Keywords: chemosensor
lipid sensing
supramolecular chemistry
molecular recognition
Date: 2011
Publisher: University of Missouri--Columbia
Abstract: Lipids represent an important class of biomolecules which have received little attention in the area of fluorescent sensing. Chemosensors for certain bioactive lipids would have a number of potential biochemical and biomedical applications. We have been using macrocyclic sensors to selectively detect lipids based on shape-selective hydrophobic interactions. The next generation sensors are based on open-tube shape structures, used mainly for ease of synthesis and ready functionalization with head group binding units. A series of receptors for the recognition of various lipids has been synthesized. The open-tube 102 and 103 were easily synthesized and purified compared to molecular tubes which are the previous hosts for the recognition of lipids. The open-tube sensors 102 and 103 were used in fluorescence titrations with a variety of lipids. Changes in the fluorescence emission were observed for most guests. The longer straight chain lipids were bound with higher affinity than shorter lipids. The greater hydrophobic surface of longer chain lipids renders them less soluble in water. The straight chain alcohols have been shown much higher association constant because they have less repulsion with carboxylates of sensors. The binding of open-tubes and lipids are less selective than those of the molecular tubes.
URI: http://hdl.handle.net/10355/15998
Other Identifiers: LeeJ-031111-D5327

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