A model of post-traumatic stress disorder (PTSD)-induces insomnia in C57BL/6J mice
Metadata[+] Show full item record
Repeated exposure to stressful conditions leads to post-traumatic stress disorder (PTSD), which affects about 60% of U.S. combat veterans and 8% of U.S. adults. PTSD is characterized by persistent re-experienceing of the traumatic event after triggering by conditions that resemble or symbolize them; hyperarousal is one of the core features. Lack of suitable animal models of stress-induced PTSD with hyperarousal has limited our understanding of the underlying mechanisms and developing therapies. The present study was designed to develop an animal model of PTSD that will display hyperarousal.