How often can PPIs be successfully withdrawn from patients with GERD?
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A small percentage (14%-21%) of patients with gastroesophageal reflux disease (GERD) can successfully stop proton pump inhibitor (PPI) treatment without developing recurrent symptoms (SOR: B, RCT and cohort study). On-demand PPI therapy leads to better control of GERD symptoms than completely terminating therapy (SOR: B, systematic review of heterogeneous RCTs).
Evidence Based Practice 15(11): 08-09.