What is the clinical significance of the interaction of clopidogrel and PPIs?
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The use of proton pump inhibitors (PPI) with clopidogrel and aspirin reduces the rate of adverse gastrointestinal (GI) events (SOR: B, RCT). The evidence is conflicting on cardiovascular outcomes in cardiac patients receiving clopidogrel and a PPI (no SOR given).
Evidence Based Practice 15(11): 09-10.