Should a Cytobrush be used for Pap smears in pregnant patients?
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Obtaining a Pap smear with a Cytobrush and Ayre spatula results in better collection of endocervical cells than using a cotton or Dacron swab and Ayre spatula (SOR: A, consistent RCTs). The Cytobrush may be associated with more spotting, but is not associated with serious adverse effects in pregnancy (SOR: B, RCTs with heterogeneous outcomes).
Evidence Based Practice 15(12): 17.