What is the differential diagnosis for isolated lymphadenopathy in children?
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Most isolated lymphadenopathy (LAD) in children is the result of either a reactive LAD or an acute lymphadenitis secondary to infection. In patients referred for persistent LAD, malignancy rates range from 5% to 24% of cases. Acute isolated LAD is rarely malignant; approximately 70% of malignant cases present with generalized LAD (SOR: B, retrospective studies).
Evidence-based practice 15, no. 12 (2012): 24-25