What medications are safe and effective for heartburn during pregnancy?
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Antacids are effective for heartburn symptoms during pregnancy (SOR: B, small RCTs). The effects of H2 blocker and (proton pump inhibitor) PPI medications are not well studied. However, H2 blockers are likely safe. PPI safety studies are mixed, with some evidence of an increase in birth defects if mothers are exposed to PPIs prior to conception through the first trimester (SOR: B, meta-analysis, cohort studies).
Evidence-based practice 15, no. 12 (2012): 12-13