What medications are best for DPN?
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Tricyclic antidepressants, duloxetine, pregabalin, oxycodone, and tramadol are all effective for the symptomatic treatment of painful diabetic neuropathy (SOR: A, systematic reviews of RCTs and single RCTs). Gabapentin is also effective (SOR: B, systematic review of RCTs with methodologic flaws). Studies directly comparing tricyclic antidepressants with gabapentin or duloxetine show equivalent efficacy (SOR: A, systematic reviews of RCTs and single RCTs). The outcome evaluated in all of these studies was pain.
Evidence-based practice 16, no. 01 (2013): 01-02