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dc.contributor.authorJavadi, Pooriaeng
dc.contributor.authorNair, Satish S., 1960-eng
dc.contributor.authorSmith, Wesleyeng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameSummer Undergraduate Research and Creative Achievements Forum (2004 : University of Missouri--Columbia)eng
dc.date2004eng
dc.date.issued2004eng
dc.descriptionAbstract only availableeng
dc.description.abstractThe alternation in firing patterns of medium spiny neurons of the Nucleus Accumbens , a key structure in the brain's reward pathway, due to chronic and acute cocaine use was investigated through change of ion channel and receptor properties. Cocaine causes cellular changes both in the proteomic and genomic level in medium spiny neurons by increasing the concentration of the neurotransmitter Dopamine in the synaptic region; therefore generating a biologically realistic model of the nucleus accumbens is necessary. Medium spiny neurons exhibit bistability, meaning that they pass through up (polarized) and down (hyperpolarized) phases of membrane potential periodically. Only in the up state will a cell fire a train of action potentials. First step in the long term project of studying cocaine addiction is modeling this complex firing pattern and quantifying what can cause it to change. This task required figuring out all the key ion channels and receptors that mediate bistability, the equations that govern their behavior, and finally putting everything together in a computer program called GENESIS.eng
dc.description.sponsorshipNSF-REU Biosystems Modelingeng
dc.identifier.urihttp://hdl.handle.net/10355/1715eng
dc.languageen_USeng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartof2004 Summer Undergraduate Research and Creative Achievements Forum (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.source.urihttp://undergradresearch.missouri.edu/forums-conferences/abstracts/abstract-detail.php?abstractid=eng
dc.subjectmedium spiny neuronseng
dc.subjectNucleus Accumbenseng
dc.subjectcocaine addictioneng
dc.subjectdopamineeng
dc.subjectbistabilityeng
dc.subjectfiring patternseng
dc.titleModeling firing patterns of medium spiny neuronseng
dc.typePresentationeng


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