Analysis of genetic drift within the highly repetitive KSP repeat domain and neurofilament medium [abstract]

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Analysis of genetic drift within the highly repetitive KSP repeat domain and neurofilament medium [abstract]

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/1897

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Title: Analysis of genetic drift within the highly repetitive KSP repeat domain and neurofilament medium [abstract]
Author: Golik, Benjamin; Barry, Devin; Yager, Craig; Garcia, Michael L.
Contributor: University of Missouri-Columbia. Office of Undergraduate Research
Keywords: axonal diameter
conduction velocity
Phosphorylation sites
Date: 2008
Publisher: University of Missouri--Columbia. Office of Undergraduate Research
Abstract: Axonal diameter is one key component utilized to determine conduction velocity. However, the mechanism that influences axonal diameter must be stable within a given species, but flexible enough to adjust to the evolution of larger species. Altering the number of Phosphorylation sites within the C-terminus of NF-M is one potential mechanism that can satisfy both criteria. We have evidence for expanding the number of sites in larger species. I will determine if the number of sites remains stable within a species. Taken together, these results will support the role of NF-M Phosphorylation in influencing axonal diameter.
URI: http://hdl.handle.net/10355/1897

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