Analysis of genetic drift within the highly repetitive KSP repeat domain and neurofilament medium [abstract]

Abstract

Axonal diameter is one key component utilized to determine conduction velocity. However, the mechanism that influences axonal diameter must be stable within a given species, but flexible enough to adjust to the evolution of larger species. Altering the number of Phosphorylation sites within the C-terminus of NF-M is one potential mechanism that can satisfy both criteria. We have evidence for expanding the number of sites in larger species. I will determine if the number of sites remains stable within a species. Taken together, these results will support the role of NF-M Phosphorylation in influencing axonal diameter.