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dc.contributor.authorHicks, Angelaeng
dc.contributor.authorKeerthi, Kripaeng
dc.contributor.authorGates, Kent S. (Kent Stephen), 1962-eng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2008 : University of Missouri--Columbia)eng
dc.date2008eng
dc.date.issued2008eng
dc.descriptionAbstract only availableeng
dc.description.abstractCysteine residues in proteins are readily oxidized to sulfenic acids. Sulfenic acids, in turn, can act as potent electrophiles that have been observed to form intrastrand protein crosslinks with neighboring amide or cysteine residues. Cysteine-tyrosine crosslinks have also been observed in proteins, but the mechanism(s) of their formation is not clear. In the work presented here we investigated the intramolecular reaction between a sulfenic acid and a tyrosine mimic. The results provide chemical evidence that sulfenic acids have the potential to forge intrastrand protein crosslinks with tyrosine residues in proteins.eng
dc.description.sponsorshipLife Sciences Undergraduate Research Opportunity Programeng
dc.identifier.urihttp://hdl.handle.net/10355/1921eng
dc.languageen_USeng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartof2008 Undergraduate Research and Creative Achievements Forum (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.subjectcysteine residueeng
dc.subjectintrastrand protein crosslinkseng
dc.subjectintramolecular reactioneng
dc.titleThe formation of cysteine-tyrosine crosslinks via a sulfenic acid intermediate [abstract]eng
dc.typePresentationeng


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