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dc.contributor.authorMink, Jennifereng
dc.contributor.authorMehra-Chaudhary, Ritchaeng
dc.contributor.authorBeamer, Lesa J. (Lesa Jean)eng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2008 : University of Missouri--Columbia)eng
dc.date2008eng
dc.date.issued2008eng
dc.descriptionAbstract only availableeng
dc.description.abstractEnzymes in the -D-phosphohexomutases superfamily frequently play a role in the biosynthesis of carbohydrates and glycolipids, critical for bacterial virulence and growth. -D-phosphohexomutases are being increasingly shown to play key roles in microbial infections, including enzymes from several major human pathogens. Successful inhibition of enzymes in the -D-phosphohexomutases superfamily may result in decreased bacterial growth rates, decreased virulence and greater susceptibility to traditional antibiotic treatment. As an initial step toward inhibitor design, we are conducting fragment-based screens of two structurally characterized members of the enzyme superfamily: P. aeruginosa phosphomannomutase/ phosphoglucomutase (PMM/PGM) and S. typhimurium phosphoglucomutase (PGM). Fragment based screening is a relatively new method that has been effectively used in the design of drug-like inhibitors for many systems. Crystals of PMM/PGM and PGM have been soaked with cocktails of small molecules (typical molecular weight 100-300 Da) to determine their sites of interaction with the proteins. X-ray diffraction data will be collected on these soaked crystals and the binding sites analyzed to determine the optimal interactions for effective inhibition.eng
dc.description.sponsorshipLife Sciences Undergraduate Research Opportunity Programeng
dc.identifier.urihttp://hdl.handle.net/10355/1965eng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartof2008 Summer Undergraduate Research and Creative Achievements Forum (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.titleFragment based screens of the -D-phosphohexomutases as an initial step for inhibitor designeng
dc.typePresentationeng


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