A new approach toward PTP-1B inhibition

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A new approach toward PTP-1B inhibition

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/2018

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dc.contributor.author Price, Nathan E. en
dc.contributor.author LaButti, Jason N., 1972- en
dc.contributor.author Gates, Kent S. (Kent Stephen), 1962- en
dc.date 2008 en
dc.date.accessioned 2009-07-06T19:26:14Z en
dc.date.available 2009-07-06T19:26:14Z en
dc.date.issued 2008 en
dc.identifier.uri http://hdl.handle.net/10355/2018 en
dc.description Abstract only available en
dc.description.abstract Signaling pathways for cellular metabolism, growth, proliferation, differentiation, immune response, motility, and tissue homeostasis is regulated by the phosphorylation of protein tyrosine residues on target proteins in the relevant signal transduction pathways. Phosphorylation levels of tyrosine residues are controlled by the opposing actions of two enzymes: protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Protein tyrosine kinases add phosphoryl groups while PTPs catalyze their removal. PTPs are emerging as potential drug targets for the treatment of type 2 diabetes, autoimmune diseases, osteoporosis, and cancer. PTP-1B is the archetypal PTP and its inactivation may be a viable treatment for type 2 diabetes and obesity. PTP-1B is regulated by endogenous hydrogen peroxide (H2O2), which is a known cellular signaling agent. H2O2 oxidatively-inactivates PTP-1B, and its activity is regenerated by free thiols within the cell such as glutathione. In order to facilitate enzyme regeneration the aforementioned thiol must have access to the enzyme active site. We are testing the hypothesis that small molecules can inhibit thiol-mediated reactivation of redox-inactivated PTPs. Molecules with such a property would decrease the activity of target PTPs in cells, thus enhancing cellular response to external stimuli that act through receptor protein kinases. en
dc.description.sponsorship Life Sciences Undergraduate Research Opportunity Program en
dc.language.iso en_US en
dc.publisher University of Missouri--Columbia. Office of Undergraduate Research en
dc.relation.ispartof 2008 Summer Undergraduate Research and Creative Achievements Forum (MU) en
dc.subject phosphorylation en
dc.subject tyrosine en
dc.title A new approach toward PTP-1B inhibition en
dc.type Presentation en
dc.contributor.meetingname Undergraduate Research and Creative Achievements Forum (2008 : University of Missouri--Columbia) en
dc.contributor.corporatename University of Missouri-Columbia. Office of Undergraduate Research en
dc.relation.ispartofcommunity University of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forum


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