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Characterization of the humoral immune response to a commercial staphylococcus aureus mastitis vaccine
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The objective of this thesis was to test the hypothesis that a commercial vaccine for bovine S. aureus mastitis fails to induce a humoral immune response ...
Interactions of porcine reproductive and respiratory syndrome virus with innate immune responses
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] North American field isolates of PRRSV differed in their type I IFN response with respect to induction, sensitivity and suppression. Furthermore, one ...
Micro-imaging characterization of mouse models of metastasis
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Non-invasive imaging techniques have been recently developed to characterize animal models of disease. The overarching hypothesis of this work explores ...
Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Smooth muscle cell phenotypic modulation is characterized by suppression of smooth muscle specific marker gene expression, migration, and proliferation ...
Advances in the fundamental cryobiology of mammalian oocytes
(University of Missouri--Columbia, 2007)
Having effective means to cryopreserve mammalian oocytes could increase the efficiency of managing populations of laboratory animals, increase the effectiveness of breeding programs for livestock, and improve the means by ...
In vitro evaluation of veterinary and human suture anchors in metaphyseal bone of the canine tibia
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Suture anchors, also called bone or tissue anchors, provide orthopedic surgeons a mechanism for secure fixation of soft tissues to bone. A human system ...
The role of macrophages and anti-viral antibodies in West Nile virus pathogenesis
(University of Missouri--Columbia, 2006)
Since the introduction of West Nile virus into the United States in 1999, the virus has spread throughout the continental territory of the United States and it is suspected that the virus has moved present into Mexico and ...
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)
Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ...
Modulation of the ACTH response to stress by IL-6, nitric oxide, diet and exercise
(University of Missouri--Columbia, 2006)
The release of ACTH from the anterior pituitary is one step in the activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is activated in response to stress and the secretion of ACTH is under the control ...
Autologous bone marrow-derived mesenchymal stem cell transplantation as a therapy for neuronal ceroid lipofuscinosis
(University of Missouri--Columbia, 2007)
The Neuronal Ceroid Lipofuscinoses (NCLs) are a group of rare genetic diseases characterized by neurodegeneration and accumulation of autofluorescent lysosomal storage bodies in numerous cell types. There are currently no ...
A series of in vitro studies investigating the role of lactoferrin in calf innate immunity
(University of Missouri--Columbia, 2006)
Neonatal calf mortality rates continue to impact the economic sustainability of the United States cattle industry. Based on data generated from the National Animal Health Monitoring System survey in 2001, 8.9 % of dairy ...
The cystic fibrosis transmembrane conductance regulator and acid-base transporters of the murine duodenum
(University of Missouri--Columbia, 2006)
The alkaline mucus barrier of the duodenum plays an important role in protecting the epithelium from acidic chyme entering from the stomach. Active HCO₃⁻ secretion involves the apical membrane activities of the cystic ...
Sensory integration during blood loss in conscious rabbits
(University of Missouri--Columbia, 2006)
Central nervous system integration of sensory inputs is critical for orchestrating physiological responses to stress. The focus of my doctoral research was investigating the physiological consequences of sensory stimulation ...
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)
Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ...
The effect of free fatty acids on endothelial cells
(University of Missouri--Columbia, 2005)
The purpose of this thesis was to determine if specific components of oxidized low density lipoprotein (OxLDL) molecules e.g. oxidized polyunsaturated fatty acids (PUFAs), or saturated free fatty acids (FFA) are alone ...
A missense mutation in Atf2 in standard poodles with fatal neonatal encephalopathy
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Neonatal encephalopathy with seizures (NEWS) is a previously undescribed autosomal recessive disease in Standard Poodles. Affected puppies are small ...
Mechanisms regulating skeletal muscle satellite cell cycle progression
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Skeletal muscle fibers are multinucleated with each myonucleus capable of governing a finite cytoplasmic volume. In healthy skeletal muscle, myonuclear ...
Mechanism of matrix metalloproteinase-14 (mmp-14) regulation during atherosclerosis
(University of Missouri--Columbia, 2006)
Atherosclerosis is characterized by the narrowing of the arterial lumen due to formation of the plaque within the intimal layer of the arterial wall resulting in the impaired flow of blood to the target organs. Most severe ...
Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis
(University of Missouri--Columbia, 2006)
Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen and an angiogenic factor. Angiogenesis regulated by VEGF is a critical event in the pathogenesis of Osteoarthritis (OA). Over-expression of VEGF in ...
Phylogenetic characterization of canine distemper viruses detected in naturally infected North American dogs
(University of Missouri--Columbia, 2006)
In 2004, dogs with clinical signs suggestive of viral disease known as canine distemper virus (CD) were referred to the University of Missouri Veterinary Diagnostic Laboratory for testing. From eleven such cases, a diagnosis ...