RSS 1.0Department of Veterinary Pathobiology (MU)
The Department of Veterinary Pathobiology is one of three academic departments that comprise the College of Veterinary Medicine at the University of Missouri. The Department has a diverse faculty committed to a multidisciplinary molecular approach to the study of animal health and animal models of human disease and to provide diagnostic service to the state and the nation. Our mission is to acquire, advance and disseminate knowledge in the fields of pathology, parasitology, microbiology, immunology, laboratory animal medicine, comparative medicine, genetics and related disciplines that will ultimately lead to better diagnosis, control and prevention of animal diseases.
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Functional myology of the primate head and neck with implications for hominin evolution
(University of Missouri--Columbia, 2021)[EMBARGOED UNTIL 5/1/2025] The primate nuchal region has been widely cited as reflecting postural and locomotor behaviors. Postural and locomotor reconstructions of fossil primates, particularly fossil hominins, have relied ... -
Shift from primary pneumonic to secondary septicemic plague by decreasing the volume of intranasal challenge with Yersinia pestis in the murine model
(Public Library of Science, 2019)Yersinia pestis is the causative agent of pneumonic plague, a disease involving uncontrolled bacterial growth and host immunopathology. Secondary septicemic plague commonly occurs as a consequence of the host inflammatory ... -
Yersinia pestis exploits early activation of MyD88 for growth in the lungs during pneumonic plague
(American Society for Microbiology, 2019)Yersinia pestis causes bubonic, pneumonic, and septicemic plague. Although no longer responsible for pandemic outbreaks, pneumonic plague continues to be a challenge for medical treatment and has been classified as a ... -
A homozygous ADAMTS2 nonsense mutation in a Doberman Pinscher dog with Ehlers Danlos syndrome and extreme skin fragility
(Blackwell Publishing Ltd, 2019)An eight-week old Doberman Pinscher was diagnosed with Ehlers Danlos syndrome based on the dog's hyper-mobile carpal, tarsal and stifle joints and abnormal skin. The skin was loose and hyper-elastic with several wounds and ... -
Discovery of novel hepatitis B virus (HBV) antivirals and analysis of mechanisms of action of HBV-targeting agents
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Chronic hepatitis B virus (HBV) infection leads to liver disease, cirrhosis, and hepatocellular carcinoma. Globally, an estimated 50% of all hepatocellular ... -
Biochemical characteristics of different subtypes of human immunodeficiency virus type 1 reverse transcriptase and its interactions with the host factor : apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). Whereas HIV-2 accounts for 5% of global infections, HIV-1 is ... -
Transcriptome profiling of rattus norvegicus embryonic stem cells by RNA-sequencing
(University of Missouri--Columbia, 2014)Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ... -
Dietary nutrients implicated in the etiopathogenesis of human and animal diseases
(University of Missouri--Columbia, 2017)Hyperthyroidism is a spontaneous disease that results in an abnormal elevation of circulating concentrations of one or more thyroid hormones. Despite being the most commonly diagnosed endocrine disorder of domestic cats, ... -
Investigation of novel therapeutic strategies for attenuating corneal fibrosis
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corneal fibrosis (scarring) is a significant cause of vision loss worldwide resulting from an exuberant wound healing response driven in part by the ... -
Complex microbiota targeted rederivation (CMTR) as an alternative method to study effect of gut microbiota on host physiology /
(University of Missouri--Columbia, 2016)Rodent models are invaluable tools to study the effects of differing gut microbiota (GM) on health and disease. Our laboratory has demonstrated that mouse GM profiles vary among animal vendors suggesting that subtle ... -
Discovering disease causing variants in dogs through whole genome sequencing
(University of Missouri--Columbia, 2017)This dissertation focuses on the use of whole genome sequencing (WGS) for the identification of disease causing variants in canine genomes. A brief review on the historical milestones of genetics, the creation and ... -
Yersinia pestis YopJ, YopT, and YopK coordinate programmed cell death and cytokine responses to promote pneumonic plague
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ... -
Development of the human ex vivo split tissue osteoarthritis model
(University of Missouri--Columbia, 2017)Osteoarthritis (OA) is a disease characterized by loss of functional articular cartilage with associated whole-joint pathology and resultant pain and disability, which is projected to affect 59.4 million Americans by 2020. ... -
Development and characterization of a novel meniscal extracellular matrix-derived scaffold /
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Despite advances in orthopaedic surgery, effective treatments ... -
Intermedilysin-mediated cell ablation in the rat and zebrafish
(University of Missouri--Columbia, 2016)Current methodologies of cell ablation have limitations with respect to the types of cells that can be targeted, the lack of specificity of ablation and the lack of appropriate methodologies to facilitate their use across ... -
Inflammatory and cardiac response to end-stage pneumonic plague
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is the etiologic agent of pneumonic plague, a devastating disease in humans characterized by acute bronchopneumonia that is frequently ... -
Cellular and molecular mechanisms underlying immune tolerance against type 1 diabetes /
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D), also known as insulin-dependent diabetes mellitus, is a chronic autoimmune disease caused by the destruction of insulin-producing ... -
Restriction of HIV by TIM-family proteins and antagonism by NEF /
(University of Missouri--Columbia, 2016) -
Microbiota modulation of behavior and stress responses : implications for neuro-immune research in zebrafish
(University of Missouri--Columbia, 2016)The gut microbiota (GM) consists of a large microbial community whose collective set of genes encodes a vast array of functions. These microbes play a major role in many physiological processes within the host and are ... -
Assessment of biomarker production by osteoarthritic osteochondral tissues and correlation to the biomechanical, biochemical, and histological properties
(University of Missouri--Columbia, 2016)Osteoarthritis (OA) is the most prevalent form of arthritis and is a significant cause of pain and disability worldwide. Treatment options available are only capable of controlling symptoms until progression to end-stage ...