Clinical Inquiries

Description: Clinical Inquiries provide the ideal answers to clinical questions: using a structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review. Clinical Inquiries deliver best evidence for point of care use.
Publisher: Family Physicians Inquiries Network
Frequency: Irregular

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Recent Submissions

  • What medical therapies work for gastroparesis? 

    Wells, Orion; Warcola, Ashley; Neher, Jon; Safranek, Sarah (2018-11)
    Q: What medical therapies work for gastroparesis? Evidence-based answer: It’s unclear if there are any highly effective medications for gastroparesis (TABLE1-10). Metoclopramide improves the sense of fullness by about 40% ...
  • What’s the best VTE treatment for patients with cancer? 

    Pham, Thuy; Sundquist, Hannah; Kelsberg, Gary; Safranek, Sarah (2018-10)
    Q: What’s the best VTE treatment for patients with cancer? Evidence-based answer: No. Head-to-head studies directly compare all the main treatments for venous thromboembolism (VTE) in cancer patients. Long-term treatment ...
  • How effectively do ACE inhibitors and ARBs prevent migraines? 

    Morris, Brendan; Neher, Jon; Safranek, Sarah (2018-10)
    Q: How effectively do ACE inhibitors and ARBs prevent migraines? Evidence-based answer: The angiotensin-converting enzyme (ACE) inhibitor lisinopril reduces the number of migraines by about 1.5 per month in patients ...
  • Do statins alter the risk or progression of dementia? 

    Tang, Tess; Clifton, Jospeh; Neher, Jon; Safranek, Sarah (2018-09)
    Q: Do statins alter the risk or progression of dementia? Evidence-based answer: No. Moderate-intensity statin therapy (with pravastatin or simvastatin) doesn’t prevent progression to dementia in patients at increased risk. ...
  • How often does long-term PPI therapy cause clinically significant hypomagnesemia? 

    Plaut, Timothy; Graeme, Katelyn; Stigleman, Sue; Hulkower, Stephen; Woodall, Tasha (2018-09)
    Q: How often does long-term PPI therapy cause clinically significant hypomagnesemia? EVIDENCE-BASED ANSWER: Rarely. Proton pump inhibitors (PPIs) may be associated with decreases in serum magnesium laboratory values to ...
  • What’s the best secondary treatment for patients who fail initial triple therapy for H pylori? 

    Jones, Leanne; Ta, Julien; Kelsberg, Gary (2018-08)
    Q: What’s the best secondary treatment for patients who fail initial triple therapy for H pylori? Evidence-based answer: treating patients with Helicobacter pylori infection who have failed clarithromycin-based triple ...
  • Can CBT effectively treat adult insomnia disorder? 

    Fox, Steven; Nashelsky, Joan; Jack, Michael (2018-07)
    Q: Can CBT effectively treat adult insomnia disorder? Evidence-based answer: Yes. Cognitive behavioral therapy (CBT) administered individually, in a group setting, or on the internet is effective for treating insomnia in ...
  • What are the benefits/risks of giving betamethasone to women at risk of late preterm labor? 

    Dresang, Lee; Hooper-Lane, Christopher (2018-07)
    Q: What are the benefits/risks of giving betamethasone to women at risk of late preterm labor? Evidence-based answer: Giving betamethasone to women at risk for delivery between 34 weeks 0 days and 36 weeks 6 days can lower ...
  • Does prophylactic azithromycin reduce the number of COPD exacerbations or hospitalizations? 

    Lyon, Corey; Radi, Roxanne; Staff, Thomas; Nashelsky, Joan (2018-06)
    Q Does prophylactic azithromycin reduce the number of COPD exacerbations or hospitalizations? EVIDENCE-BASED ANSWER: Yes for exacerbations, no for hospitalizations. Prophylactic azithromycin reduces the number of exacerbations ...
  • How effective and safe is fecal microbial transplant in preventing C difficile recurrence? 

    Meyers, Shawn; Shin, Jessica; Neher, Jon O.; Safranek, Sarah (2018-06)
    Q: How effective and safe is fecal microbial transplant in preventing C difficile recurrence? Evidence-based answer: fecal microbial transplant (fmt) is reasonably safe and effective. In patients who have had multiple ...
  • How effective and safe is fecal microbial transplant in preventing C difficile recurrence? 

    Meyers, Shawn; Meyers, Shawn; Shih, Jessica; Neher, Jon O. (2018-06)
    Q. How effective and safe is fecal microbial transplant in preventing C difficile recurrence? Evidence-based answer: fecal microbial transplant (fmt) is reasonably safe and effective. In patients who have had multiple ...
  • Does niacin decrease cardiovascular morbidity and mortality in CVD patients? 

    Lazzopina, Peter; Mounsey, Anne; Handler, Lara (Family Physicians Inquiries Network, 2018-05)
    Q: Does niacin decrease cardiovascular morbidity and mortality in CVD patients? A: No. Niacin doesn’t reduce cardio- vascular disease (CVD) morbidity or mortality in patients with established disease (strength of ...
  • What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events? 

    Mutter, Justin; Grandy, Rebecca; Hulkower, Stephen; Stigleman, Sue (Family Physicians Inquiries Network, 2018-04)
    Q: What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events? A: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years ...
  • How well do POLST forms assure that patients get the end-of-life care they requested? 

    Collier, Jordan; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2018-04)
    Q: How well do POLST forms assure that patients get the end-of-life care they requested? A: quite well, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select “do not resuscitate” (DNR) on their ...
  • Does exercise relieve vasomotor menopausal symptoms? 

    Lyon, Corey; Mullen, Rebecca; Deffenbacher, Brandy; Reed, Alex; Nashelsky, Joan (Family Physicians Inquiries Network, 2018-03)
    Q: Does exercise relieve vasomotor menopausal symptoms? A: NO. Exercise doesn’t decrease the frequency or severity of vasomotor menopausal symptoms (VMS) in perimenopausal and postmenopausal women (strength of recommendation: ...
  • How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury? 

    Lyon, Corey; Piggott, Susan; Langner, Shannon; Desanto, Kristen (Family Physicians Inquiries Network, 2018-02)
    Q: How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury? A: nonsteroidal anti-inflammatory drugs(NSAIDs) are at least as effective as other oral analgesics (opioids, acetaminophen) ...
  • Is megestrol acetate safe and effective for malnourished nursing home residents? 

    Wen, Frances K.; Millar, James; Oberst-Walsh, Linda; Nashelsky, Joan (Family Physicians Inquiries Network, 2018-02)
    Q: Is megestrol acetate safe and effective for malnourished nursing home residents? A: no. Megestrol acetate (MA) is neither safe nor effective for stimulating appetite in malnourished nursing home residents. It increases ...
  • How do hyaluronic acid and corticosteroid injections compare for knee OA relief? 

    Lyon, Corey; Spencer, Emily; Spittler, Jack; Desanto, Kristen (Family Physicians Inquiries Network, 2017-01)
    Q How do hyaluronic acid and corticosteroid injections compare for knee OA relief? A: Inconsistent evidence shows a small amount of pain relief early (one week to 3 months) with corticosteroid (CS) injections and an equally ...
  • Which interventions are effective in managing parental vaccine refusal? 

    Brelsford, Dan; Knutzen, Elise; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2017-12)
    Q: Which interventions are effective in managing parental vaccine refusal? A: it’s unclear whether educational initiatives alone alter vaccine refusal. Although about a third of parents cite herd immunity as motivation for ...
  • What is the optimal frequency for dental checkups for children and adults? 

    Hahn, Thomas W.; Kraus, Connie; Hooper-Lane, Christopher (Family Physicians Inquiries Network, 2017-11)
    Q: What is the optimal frequency for dental checkups for children and adults? A: It is unclear, but studies suggest that it should be based largely on individual risk. The American Academy of Pediatric Dentistry recommends ...

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