Clinical Inquiries

Description: Clinical Inquiries provide the ideal answers to clinical questions: using a structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review. Clinical Inquiries deliver best evidence for point of care use.
Publisher: Family Physicians Inquiries Network
Frequency: Irregular

Collections in this community

Recent Submissions

  • Should RAAS blockade therapy be continued in patients with advanced renal disease? 

    Pham, Kim; Beyer, Carli; Guthmann, Rick (Family Physicians Inquiries Network, 2023-04)
    Q: Should RAAS blockade therapy be continued in patients with advanced renal disease? Evidence-based answer: PROBABLY. Renin-angiotensinaldosterone system (RAAS) blockade therapy should be continued in most patients with ...
  • Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? 

    Reddy, Vinay; Allison, James; Mounsey, Anne; Guthmann, Rick (Family Physicians Inquiries Network, 2023-06)
    Q: Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? Evidence-based answer: YES. In patients with known cardiovascular disease (CVD), ezetimibe with a statin decreases major adverse ...
  • Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? 

    Dresang, Lee; Vellardita, Lia; Guthmann, Rick (Family Physicians Inquiries Network, 2023-03)
    Q: Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? Evidence-based answer:Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; ...
  • Is low-dose naltrexone effective in chronic pain management? 

    Radi, Roxanne; Huang, Harriet; Rivera, Jason; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-09)
    Q: Is low-dose naltrexone effective in chronic pain management? Evidence-based answer: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety ...
  • Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? 

    Wen, Frances K.; Bigelow, Simone; Crosby, Kimberly; Reeder, Raye; Hoberecht, Toni; Moreau, Emrys; Guthmann, Rick (Family Physicians Inquiries Network, 2023-07)
    Q: Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? Evidence-based answer: NO. In adults with insulin-treated type 2 diabetes (T2D), continuous glucose monitoring (CGM) and flash ...
  • Does regular walking improve lipid levels in adults? 

    Hatchell, Kayla; Chin, Emily; Vukelic, Brian; Fortenberry, Katherine; Ose, Dominick; Taylor, Eliza; Goossen, Rachel; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: Minimally. Regular moderateintensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC) and low-density lipoprotein (LDL) levels by about 7 mg/dL in women with ...
  • Does physical exercise reduce dementia-associated agitation? 

    Jabbour, Katarzyna; Wilson, Lynn M.; Mathieu, Susan S.; Keister, Drew; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: not consistently. Physical exercise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation, in patients with dementia (strength of recommendation: b, inconsistent ...
  • Does hormone replacement therapy prevent cognitive decline in postmenopausal women? 

    Gates, Madeline; Beagle, Melissa; Bull, Lauren; Radi, Roxanne; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-05)
    Q: Evidence-based answer: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may slightly increase risk (strength of recommendation, A; systematic review, ...
  • How does gender-affirming hormone therapy affect QOL in transgender patients? 

    Wilhelm, Sarah; Kelsberg, Gary; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-12)
    Q: How does gender-affirming hormone therapy affect QOL in transgender patients? Evidence-based answer: There are modest effects on depression but not anxiety. Gender-affirming hormone therapy (GAHT) is associated with ...
  • How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? 

    Boden, Brandi; Buescher, Brittany; Kim, Amanda; Neher, Jon O.; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-11)
    Q: How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? Evidence-based answer: Fairly accurate. Photometric transcutaneous bilirubin (TcB) testing may overestimate total serum bilirubin (TSB) ...
  • Does an early COPD diagnosis improve long-term outcomes? 

    Bernet, Dan; Randolph, Charles; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2022-10)
    Q Does an early COPD diagnosis improve long-term outcomes? Evidence-based answer: It depends. A diagnosis of chronic obstructive pulmonary disease (COPD) made using screening spirometry in patients without symptoms does ...
  • What barriers delay treatment in patients with hepatitis C? 

    Crosby, Kimberly; Bigelow, Simone; Sachs, Viviane; Weakley, Jennifer; Skaftason, Helga; Hoberecht, Toni (Family Physicians Inquiries Network, 2022-09)
    Q: What barriers delay treatment in patients with hepatitis C? Evidence-based answer: Multiple patient-specific and provider-perceived factors delay initiation of treatment in patients with hepatitis C. Patient-specific ...
  • Does platelet-rich plasma improve patellar tendinopathy symptoms? 

    Wolfenden, Emily; Vukelic, Brian; DeMarco, Matthew; Knox, Jordan; Ose, Dominik (Family Physicians Inquiries Network, 2022-05)
    Q: Does platelet-rich plasma improve patellar tendinopathy symptoms? Evidence-based answer: IT’S UNCLEAR. High-quality data have not consistently established the effectiveness of platelet-rich plasma (PRP) injections to ...
  • Should we stop prescribing IM progesterone to women with a history of preterm labor? 

    Dresang, Lee; Vellardita, Lia (Family Physicians Inquiries Network, 2022-01)
    Q: Should we stop prescribing IM progesterone to women with a history of preterm labor? Evidence-based answer: YES, we should stop the routine prescribing of IM progesterone to prevent preterm delivery. A 2003 randomized ...
  • Are SERMs safe and effective for the treatment of hypogonadism in men? 

    Joseph, Tina; Gibbs, Lawrence M.; Pham, Kim (Family Physicians Inquiries Network, 2022-01)
    Q: Are SERMs safe and effective for the treatment of hypogonadism in men? Evidence-based answer: YES. For both normal-weight and obese men with low testosterone levels and hypogonadal symptoms, selective estrogen receptor ...
  • Does adjunctive oxytocin infusion during balloon cervical ripening improve labor induction? 

    Dubay, Rachel; Rentschler, Nicola; Jolly, Dara; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2022-03)
    Q: Does adjunctive oxytocin infusion during balloon cervical ripening improve labor induction? Evidence-based answer: YES. Compared to the use of a transcervical balloon alone, combined cervical ripening with a balloon ...
  • Is bicarbonate therapy effective in preventing CKD progression? 

    Ahmad, Harls; Wertin, Theresa; Zhang, Yilin; Neher, Jon O.; Auten, Beth (Family Physicians Inquiries Network, 2022-04)
    Q: Is bicarbonate therapy effective in preventing CKD progression? Evidence-based answer: YES. Long-term sodium bicarbonate therapy slightly slows the loss of renal function in patients with chronic kidney disease (CKD) ...
  • Is nonoperative treatment effective for acute Achilles tendon rupture? 

    Silver, Sabrina; Fulleborn, Stephanie; Feola, Nolan; Giblin, Sydney (Family Physicians Inquiries Network, 2022-06)
    Q: Is nonoperative treatment effective for acute Achilles tendon rupture? Evidence-based answer: YES. Nonoperative and open surgical interventions provide equal long-term functional outcomes of the affected Achilles tendon ...
  • Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression? 

    Bleacher, Heather; Koerperich, Lindsay; Malam, Naomi; DeSanto, Kristen (Family Physicians Inquiries Network, 2022-07)
    Q: Are antipsychotics effective adjunctive Tx for patients with moderate-to-severe depression? Evidence-based answer: YES. Augmentation with second-generation antipsychotics, especially aripiprazole and quetiapine, appears ...
  • Do behavioral interventions improve nighttime sleep in children < 1 year old? 

    Hungenberg, Morgan; Houss, BreAnna; Narayan, Madhav; Lyon, Corey; DeSanto, Kristen (Family Physicians Inquiries Network, 2022-07)
    Q: Do behavioral interventions improve nighttime sleep in children < 1 year old? Evidence-based answer: YES. Infants respond to behavioral interventions, although objective data are limited. Behavioral interventions include ...

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