Clinical Inquiries

Description: Clinical Inquiries provide the ideal answers to clinical questions: using a structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review. Clinical Inquiries deliver best evidence for point of care use.
Publisher: Family Physicians Inquiries Network
Frequency: Irregular

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Recent Submissions

  • What effects -- if any -- does marijuana use during pregnancy have on the fetus or child? 

    Zhang, Angela; Marshall, Robert; Kelsberg, Gary; Safranek, Sarah; Neher, Jon (Family Physicians Inquiries Network (FPIN), 2017)
    What effects -- if any -- does marijuana use during pregnancy have on the fetus or child? Evidence-based answer: The effects are unclear. Marijuana use during pregnancy is associated with clinically unimportant lower birth ...
  • Do oral decongestants have a clinically significant effect on BP in patients with hypertension? 

    Hollander- Rodriguez, Joyce C.; Montjoy, Holly L.; Smedra, Brynn; Prouty, J. P.; Hamilton, Andrew; Guthmann, Richard (Family Physicians Inquiries Network (FPIN), 2017)
    Do oral decongestants have a clinically significant effect on BP in patients with hypertension? Evidence-based answer: It is unclear. Pseudoephedrine causes an average increase of 1.2 mm Hg in systolic blood pressure (BP) ...
  • Do ACE inhibitors or ARBs help prevent kidney disease in patients with diabetes and normal BP? 

    Trietley, Gregory S.; Wilson, Stephen A.; Chaudhri, Parul; Payette, Nicole (2017-04)
    Q: Do ACE inhibitors or ARBs help prevent kidney disease in patients with diabetes and normal BP? Evidence-based answer: Yes for angiotensin-converting enzyme (ACE) inhibitors, no for angiotensin receptor blockers (ARBs). ...
  • Can mobile technology improve weight loss in overweight and obese patients? 

    Harris, Lisa M.; Mounsey, Anne; Nashelsky, Joan (Family Physicians Inquiries Network, 2017-02)
    Q: Can mobile technology improve weight loss in overweight and obese patients? Evidence-based answer: Yes, this technology can help in the short term. Mobile technology compared with minimal or no intervention increases ...
  • Do pedometers increase activity and improve health outcomes? 

    Schock, Devin; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2017-01)
    Q: Do pedometers increase activity and improve health outcomes? Evidence-based answer: yes. In overweight and obese patients, exercise interventions using a pedometer increase steps by about a mile per day over the same ...
  • Does vitamin D without calcium reduce fracture risk? 

    Daly, Sarah; Allison, Cami; Nashelsky, Joan (Family Physicians Inquiries Network, 2016-12)
    Q: Does vitamin D without calcium reduce fracture risk? Evidence-based answer: No. Supplemental vitamin D without calcium -- in doses averaging as much as 800 IU per day -- doesn't reduce the risk of hip, vertebral, or ...
  • Does breastfeeding affect the risk of childhood obesity? 

    Gunnell, Lindsay; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2016-12)
    Q: Does breastfeeding affect the risk of childhood obesity? Evidence-based answer: Yes. Even having breastfed during the first year of life is associated with a 15% lower risk of overweight or obesity over the next 2 to ...
  • Does knuckle popping lead to arthritis? 

    Powers, Tye; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-10)
    Q: Does knuckle popping lead to arthritis? Evidence-based answer: No, habitual knuckle popping, or cracking (over the course of several decades) isn't associated with clinical or radiographic evidence of osteoarthritis ...
  • Which SSRIs most effectively treat depression in adolescents? 

    DeLucia, Valory; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-09)
    Q: Which SSRIs most effectively treat depression in adolescents? Evidence-based answer: We don' t know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared ...
  • Which treatments are safe and effective for chronic sinusitis? 

    Over, Darrell R. (Family Physicians Inquiries Network, 2016-11)
    Q: Which treatments are safe and effective for chronic sinusitis? Evidence-based answer: for adults with chronic rhinosinusitis (crs), intranasal steroid (ins) therapy is more likely than placebo to improve symptoms (50% ...
  • Which patients with metabolic syndrome benefit from metformin? 

    Stover, Liz; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-11)
    Q Which patients with metabolic syndrome benefit from metformin? Evidence-based answer: Patients at highest risk for progression to diabetes benefit from metformin. In patients with metabolic syndrome who are in the ...
  • How do clinical prediction rules compare with joint fluid analysis in diagnosing gout? 

    Westerfield, Katie L; Mounsey, Anne; Nashelsky, Joan (Family Physicians Inquiries Network, 2016-11)
    Q: How do clinical prediction rules compare with joint fluid analysis in diagnosing gout? Evidence-based answer: Clinical prediction rules effectively diagnose gout without joint fluid analysis. The American College of ...
  • Which nonhormonal treatments are effective for hot flashes? 

    Kelsberg, Gary; Maragh, Leticia; Safranek, Sarah (Family Physicians Inquiries Network, 2016-05)
    Q: Which nonhormonal treatments are effective for hot flashes? Evidence-based answer: Selective serotonin reuptake inhibitors (SSRIs [fluoxetine, sertraline, paroxetine]) and the selective norepinephrine reuptake inhibitor ...
  • Does caffeine intake during pregnancy affect birth weight? 

    Adams, Taralee; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-03)
    Q: Does caffeine intake during pregnancy affect birth weight? Evidence-based answer: No. Reducing caffeinated coffee consumption by 180 mg of caffeine (the equivalent of 2 cups) per day after 16 weeks-gestation doesn't ...
  • Is lower BP worth it in higher-risk patients with diabetes or coronary disease? 

    Kelsberg, Gary; Russell, Telly; Safranek, Sarah (Family Physicians Inquiries Network, 2016-02)
    Q: Is lower BP worth it in higher-risk patients with diabetes or coronary disease? Evidence-based answer: There is no simple answer; the risk/benefit picture is complicated. Controlling blood pressure to a target of 130/80 ...
  • Do corticosteroid injections improve carpal tunnel syndrome symptoms? 

    Lyon, Corey; Syfert, Jonathan; Nashelsky, Joan (Family Physicians Inquiries Network, 2016-02)
    Q: Do corticosteroid injections improve carpal tunnel syndrome symptoms? Evidence-based answer: Yes. injected corticosteroids reduce symptoms of carpal tunnel syndrome (CTS) more effectively than placebo or systemic steroids, ...
  • What’s the best way to predict the success of a trial of labor after a previous C-section? 

    Warren, Johanna B.; Hamilton, Andrew (Family Physicians Inquiries Network, 2015-12)
    Q: What's the best way to predict the success of a trial of labor after a previous C-section? Evidence-based answer: while 8 scoring tools predict success rates for a trial of labor after previous cesarean section (TOLAC), ...
  • Is arthroscopic subacromial decompression effective for shoulder impingement? 

    Ashbaugh, Andrew; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2015-11)
    Q: Is arthroscopic subacromial decompression effective for shoulder impingement? Evidence-based answer: It's impossible to say for certain in the absence of randomized controlled trials. However, in patients whose impingement ...
  • Does high dietary soy intake affect a woman’s risk of primary or recurrent breast cancer? 

    Eakin, Angie; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2015-10)
    Q. Does high dietary soy intake affect a woman's risk of primary or recurrent breast cancer? Evidence-based answer: No, it doesn't affect the risk of primary breast cancer, but it does (favorably) affect the risk of cancer ...
  • How effective are opioids for chronic low back pain? 

    Freund, Jeffrey; Kraus, Connie; Hopper-Lane, Christopher (Family Physicians Inquiries Network, 2015-09)
    Q: How effective are opioids for chronic low back pain? Evidence-based answer: Short-term (<4 months) treatment with opioids provides modest relief of chronic low back pain, but only minimal improvement in function compared ...

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