Clinical Inquiries

Description: Clinical Inquiries provide the ideal answers to clinical questions: using a structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review. Clinical Inquiries deliver best evidence for point of care use.
Publisher: Family Physicians Inquiries Network
Frequency: Irregular

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Recent Submissions

  • Does niacin decrease cardiovascular morbidity and mortality in CVD patients? 

    Lazzopina, Peter; Mounsey, Anne; Handler, Lara (2018-05)
    Q: Does niacin decrease cardiovascular morbidity and mortality in CVD patients? A: No. Niacin doesn’t reduce cardio- vascular disease (CVD) morbidity or mortality in patients with established disease (strength of ...
  • What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events? 

    Mutter, Justin; Grandy, Rebecca; Hulkower, Stephen; Stigleman, Sue (2018-04)
    Q: What are the benefits and risks of daily low-dose aspirin for primary prevention of CV events? A: One nonfatal myocardial infarction (MI) will be avoided for every 126 to 138 adults who take daily aspirin for 10 years ...
  • How well do POLST forms assure that patients get the end-of-life care they requested? 

    Collier, Jordan; Kelsberg, Gary; Safranek, Sarah (2018-04)
    Q: How well do POLST forms assure that patients get the end-of-life care they requested? A: quite well, for cardiopulmonary resuscitation (CPR). Most patients (91%-100%) who select “do not resuscitate” (DNR) on their ...
  • Does exercise relieve vasomotor menopausal symptoms? 

    Lyon, Corey; Mullen, Rebecca; Deffenbacher, Brandy; Reed, Alex; Nashelsky, Joan (2018-03)
    Q: Does exercise relieve vasomotor menopausal symptoms? A: NO. Exercise doesn’t decrease the frequency or severity of vasomotor menopausal symptoms (VMS) in perimenopausal and postmenopausal women (strength of recommendation: ...
  • How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury? 

    Lyon, Corey; Piggott, Susan; Langner, Shannon; Desanto, Kristen (2018-02)
    Q: How do oral NSAIDs compare to other oral analgesics right after an acute musculoskeletal injury? A: nonsteroidal anti-inflammatory drugs(NSAIDs) are at least as effective as other oral analgesics (opioids, acetaminophen) ...
  • Is megestrol acetate safe and effective for malnourished nursing home residents? 

    Wen, Frances K.; Millar, James; Oberst-Walsh, Linda; Nashelsky, Joan (2018-02)
    Q: Is megestrol acetate safe and effective for malnourished nursing home residents? A: no. Megestrol acetate (MA) is neither safe nor effective for stimulating appetite in malnourished nursing home residents. It increases ...
  • How do hyaluronic acid and corticosteroid injections compare for knee OA relief? 

    Lyon, Corey; Spencer, Emily; Spittler, Jack; Desanto, Kristen (2017-01)
    Q How do hyaluronic acid and corticosteroid injections compare for knee OA relief? A: Inconsistent evidence shows a small amount of pain relief early (one week to 3 months) with corticosteroid (CS) injections and an equally ...
  • Which interventions are effective in managing parental vaccine refusal? 

    Brelsford, Dan; Knutzen, Elise; Neher, Jon O.; Safranek, Sarah (2017-12)
    Q: Which interventions are effective in managing parental vaccine refusal? A: it’s unclear whether educational initiatives alone alter vaccine refusal. Although about a third of parents cite herd immunity as motivation for ...
  • What is the optimal frequency for dental checkups for children and adults? 

    Hahn, Thomas W.; Kraus, Connie; Hooper-Lane, Christopher (2017-11)
    Q: What is the optimal frequency for dental checkups for children and adults? A: It is unclear, but studies suggest that it should be based largely on individual risk. The American Academy of Pediatric Dentistry recommends ...
  • Are oral emergency contraceptives a safe & effective form of long-term birth control? 

    Kraus, Connie; Hooper-Lane, Christopher (2017-10)
    Q: Are oral emergency contraceptives a safe & effective form of long-term birth control? A: Yes, but not as effective as some other methods. Annual pregnancy rates in women using pericoital levonor- gestrel ...
  • What is the most effective treatment for scabies? 

    Campbell, Jonathon J.; Paulson, Christopher P.; Nashelsky, Joan; Guthmann, Rick (Family Physicians Inquiries Network (FPIN), 2017-08)
    Q: What is the most effective treatment for scabies? Evidence-based answer: Topical permethrin is the most effective treatment for classic scabies (strength of recommendation [SOR]: A, meta-analyses with consistent results). ...
  • What effects -- if any -- does marijuana use during pregnancy have on the fetus or child? 

    Zhang, Angela; Marshall, Robert; Kelsberg, Gary; Safranek, Sarah; Neher, Jon (Family Physicians Inquiries Network (FPIN), 2017)
    What effects -- if any -- does marijuana use during pregnancy have on the fetus or child? Evidence-based answer: The effects are unclear. Marijuana use during pregnancy is associated with clinically unimportant lower birth ...
  • Do oral decongestants have a clinically significant effect on BP in patients with hypertension? 

    Hollander- Rodriguez, Joyce C.; Montjoy, Holly L.; Smedra, Brynn; Prouty, J. P.; Hamilton, Andrew; Guthmann, Richard (Family Physicians Inquiries Network (FPIN), 2017)
    Do oral decongestants have a clinically significant effect on BP in patients with hypertension? Evidence-based answer: It is unclear. Pseudoephedrine causes an average increase of 1.2 mm Hg in systolic blood pressure (BP) ...
  • Do ACE inhibitors or ARBs help prevent kidney disease in patients with diabetes and normal BP? 

    Trietley, Gregory S.; Wilson, Stephen A.; Chaudhri, Parul; Payette, Nicole (2017-04)
    Q: Do ACE inhibitors or ARBs help prevent kidney disease in patients with diabetes and normal BP? Evidence-based answer: Yes for angiotensin-converting enzyme (ACE) inhibitors, no for angiotensin receptor blockers (ARBs). ...
  • Can mobile technology improve weight loss in overweight and obese patients? 

    Harris, Lisa M.; Mounsey, Anne; Nashelsky, Joan (Family Physicians Inquiries Network, 2017-02)
    Q: Can mobile technology improve weight loss in overweight and obese patients? Evidence-based answer: Yes, this technology can help in the short term. Mobile technology compared with minimal or no intervention increases ...
  • Do pedometers increase activity and improve health outcomes? 

    Schock, Devin; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2017-01)
    Q: Do pedometers increase activity and improve health outcomes? Evidence-based answer: yes. In overweight and obese patients, exercise interventions using a pedometer increase steps by about a mile per day over the same ...
  • Does vitamin D without calcium reduce fracture risk? 

    Daly, Sarah; Allison, Cami; Nashelsky, Joan (Family Physicians Inquiries Network, 2016-12)
    Q: Does vitamin D without calcium reduce fracture risk? Evidence-based answer: No. Supplemental vitamin D without calcium -- in doses averaging as much as 800 IU per day -- doesn't reduce the risk of hip, vertebral, or ...
  • Does breastfeeding affect the risk of childhood obesity? 

    Gunnell, Lindsay; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2016-12)
    Q: Does breastfeeding affect the risk of childhood obesity? Evidence-based answer: Yes. Even having breastfed during the first year of life is associated with a 15% lower risk of overweight or obesity over the next 2 to ...
  • Does knuckle popping lead to arthritis? 

    Powers, Tye; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-10)
    Q: Does knuckle popping lead to arthritis? Evidence-based answer: No, habitual knuckle popping, or cracking (over the course of several decades) isn't associated with clinical or radiographic evidence of osteoarthritis ...
  • Which SSRIs most effectively treat depression in adolescents? 

    DeLucia, Valory; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2016-09)
    Q: Which SSRIs most effectively treat depression in adolescents? Evidence-based answer: We don' t know which selective serotonin reuptake inhibitors (SSRIs) are the most effective and safe because no studies have compared ...

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