Clinical Inquiries

Description: Clinical Inquiries provide the ideal answers to clinical questions: using a structured search, critical appraisal, authoritative recommendations, clinical perspective, and rigorous peer review. Clinical Inquiries deliver best evidence for point of care use.
Publisher: Family Physicians Inquiries Network
Frequency: Irregular

Collections in this community

Recent Submissions

  • Q Which injections are effective for lateral epicondylitis? 

    Vukelic, Brian; Abbey, Rebecca; Knox, Jordan; Migdalski, Alyssa (2021-11)
    Evidence-based answer: placebo injections actually improve lateral epicondylitis at high rates. No other injections convincingly improve it better than placebo. Corticosteroid injection is not superior to saline or anesthetic ...
  • Q Does inadequate sleep increase obesity risk in children? 

    Herzog, Daniela; Thai, Kristin; Neher, Jon O.; Auten, Beth (2021-12)
    Evidence-based answer: Yes, a link has been established but not a cause-effect relationship. Shorter reported sleep duration in childhood is associated with an increased risk of overweight or obesity years later (strength ...
  • Q Is exercise therapy effective treatment for low back pain? 

    Broszko, Christine; Golden, Krystyna; Holmes, Cody R.; Fulleborn, Stephanie; Biglow, Carolyn (2021-11)
    Evidence-based answer: Yes, it is somewhat effective. Exercise therapy—including general exercise, yoga, Pilates, and motor control exercise—has been shown to modestly decrease pain in chronic low back pain (LBP); levels ...
  • Q Do carotid artery calcifications seen on radiographs predict stenosis in asymptomatic adults? 

    Cowdrey, Diana; Hanh, Thomas; Vellardita, Lia (Family Physicians Inquiries Network, 2021-09)
    Evidence-based answer: not very well. In asymptomatic patients, carotid artery calcification seen on radiograph has a positive predictive value of 70% and a negative predictive value of 75% for carotid artery stenosis ...
  • Q: Can family physicians accurately screen for AAA with point-of-care ultrasound? 

    Cade, Nathan; Granath, Brad; Nehr, Jon O.; Sarfranek, Sarah (Family Physicians Inquiries Network, 7/8/2021)
    Evidence-based answer: LIKELY YES. Point-of-care ultrasound (POCUS) screening for abdominal aortic aneurysm (AAA) by nonradiologist physicians is 98% sensitive and 99% specific, compared with imaging performed by radiologists ...
  • Q: Is event-driven PrEP dosing for HIV as effective as daily dosing? 

    Olsen, Tory; Lally-Montgomery, Zachary; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2021-06)
    Evidence based answer: PROBABLY, although there are no head-to-head trials comparing the 2 dosing regimens. Event-driven pre-exposure prophylaxis (PrEP) dosing reduces HIV conversion by 86% compared to placebo (strength ...
  • Q: Is NPH associated with fewer adverse events than analog basal insulin for adults with T2D? 

    Lyon, Corey; Iruku, Swetha; Hoss, Molly; DeSanto, Kristen (Family Physicians Inquiries Network, 2021-05)
    Evidence based answer: NO. Insulin glargine may lead to less patient-reported, symptomatic, and nocturnal hypoglycemia, although overall, there may not be a difference in the risk for severe hypoglycemia or hypoglycemia-related ...
  • Q: Is ketamine effective and safe for treatment-resistant depression? 

    Zorn, Amanda; Linn, Sean; Jenkinson, Mat; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2021-04)
    Evidence-based answer: Maybe, but it’s too soon to tell. There is limited evidence that ketamine by itself is effective in the very short term. Single-dose intravenous (IV) ketamine is more likely than placebo (odds ratio ...
  • Which detoxification regimens are effective for alcohol withdrawal syndrome? 

    Caspar, Rachel; Fortenberry, Katherine; Leiser, Jennifer; Ose, Dominik; Nashelsky, Joan (Family Physicians Inquiries Network, 2021)
    Q: Which detoxification regimens are effective for alcohol withdrawal syndrom? Evidence based answer: Benzodiazepines remain the first-line regimen for alcohol withdrawal syndrome (AWS) and are the only class more effective ...
  • Is metformin effective for reducing weight in obese or overweight adolescents? 

    Anderson, Kirsten; Kelsberg, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2021)
    Q: Is metformin effective for reducing weight in obese or overweight adolescents? Evidence based answer: Yes, to some degree—but it is of uncertain clinical significance. Over a period of 6 months, metformin modestly reduced ...
  • Is the incidence of depressive disorders increased following cerebral concussion? 

    Deck, Jason W.; Kern, Thomas; Cavanagh, LaMont; Bartow, Matthew; Perkins, Franklin T., III (Family Physicians Inquiries Network, 2021)
    Q: Is the incidence of depressive disorders increased following cerebral concussion? Evidence-based answer: yes, in some populations. Youth and adolescents with self-reported history of concussion had increased risk of ...
  • Introduction to Clinical Inquiries : new series by the Family Physicians Inquiries Network 

    Mott, Timothy; Guthmann, Richard (Family Physicians Inquiries Network, 2020)
    Introduction to Clinical Inquiries and FPIN. The Clinical Inquiries were included in Canadian Family Physician beginning March 2020.
  • Acupuncture for low back pain 

    Clemente Fuentes, Roselyn; Organ, Brooke; Creech, Julie; Broszko, Christine M.; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: Is acupuncture effective in improving pain relief for low back pain? Evidence-based answer: Acupuncture is an effective treatment for relief from low back pain, even when compared with other ...
  • Efficacy of a low-carbohydrate or ketogenic diet in preventing patient morbidity and mortality 

    Clemente Fuentes, Roselyn W.; Broszko, Christine M.; Pietralcyzk, Elizabeth S.; Nashelsky, Joan (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: What is the efficacy of a low-carbohydrate or ketogenic diet in the prevention of patient morbidity and mortality? Evidence-based answer: Ketogenic diets can reduce seizure incidence in refractory ...
  • Hypoglycemia with insulin and sulfonylureas 

    Kolman, Karyn B.; Freeman, Joshua; Howe, Carol L. (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: In patients with type 2 diabetes mellitus (T2DM), does the combination of insulin and sulfonylurea (SU) increase the risk of hypoglycemia? Evidence-based answer: The incidence of severe ...
  • Chlamydia test-of-cure in pregnancy 

    Pettit, Jessie; Howe, Carol; Freeman, Joshua (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: What is the optimal interval between treatment and test-of-cure (TOC) in pregnant women with Chlamydia trachomatis (CT)? Evidence-based answer: The optimal interval between treatment and TOC ...
  • Effect of corticosteroids on pain and function in knee osteoarthritis patients 

    Beggs, Luke; Stigleman, Sue; Vaughan, Aaron; Pacious, Josh; Hulkower, Stephen (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: Does the type of corticosteroid have an effect on pain and functional status of the knee in osteoarthritis (OA) patients receiving intra-articular injections? Evidence-based answer: In patients ...
  • Effective analgesic options for intrauterine device placement pain 

    Whitworth, Karena; Neher, Jon; Safranek, Sarah (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: What analgesic options are most effective for pain related to intrauterine device (IUD) placement? Evidence-based answer: Lidocaine-prilocaine cream (LPC; 2.5% lidocaine and 2.5% prilocaine) ...
  • Potential harms of long-term acne treatment with oral antibiotics 

    Dao, Minh; Kelsberg, Gary; Louden, Diana (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: What are the potential harms of long-term acne treatment with oral antibiotics? Evidence-based answer: Specific evidence attributing adverse effects to long-term acne treatment with oral ...
  • Effectiveness of dermoscopy in skin cancer diagnosis 

    Davis, Sydney; Piggot, Cleveland; Lyon, Corey; DeSanto, Kristen (Family Physicians Inquiries Network, 2020)
    Clinical Inquiries question: Does dermoscopy improve the effectiveness of skin cancer diagnosis when used for skin cancer screening? Evidence-based answer: Dermoscopy added to visual inspection is more accurate than visual ...

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