Browsing School of Medicine (MU) by Thesis Semester "2008 Spring"
Now showing items 1-9 of 9
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Alternative RNA processing and strategies to modulate splicing
(University of Missouri--Columbia, 2008)Spinal Muscular Atrophy (SMA) is a genetic disease that is intrinsically linked to an alternative RNA splicing event that leads a defective protein. To better understand how aberrant RNA processing events occur and lead ... -
Amyloid beta induces cPLA2 activation by an NADPH oxidase-dependent mechanism in neurons
(University of Missouri--Columbia, 2008)Alzheimer's disease (AD) is a neurodegenerative disorder affecting more than 20 million people worldwide. An increase in production of amyloid beta peptides (A[Beta]) and their aggregation to the oligomeric form is thought ... -
Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium
(University of Missouri--Columbia, 2008)This study examines the role of the steroid hormones, estrogen (E2) and progesterone (P4) in the regulation of TLR3-mediated mucosal immune responses in the human reproductive tract. TLR3 expression in endometrial epithelium ... -
Immunotherapy for autoimmune diabetes
(University of Missouri--Columbia, 2008)Type I diabetes (TID) is an autoimmune disorder wherein the insulin producing beta (Beta) cells of the pancreatic islets of Langerhans are destroyed specifically by the [Beta]-cell antigen specific T cells. Numerous ... -
Microbial pathogen contamination in mouse gametes and embryos
(University of Missouri--Columbia, 2008)Large numbers of transgenic and knockout mice have been generated. Cryopreservation provides an efficient and effective way to maintain these unique genetically modified rodent lines. However, there is a great risk of ... -
Molecular control of endothelial lumen formation by Rho GTPases in three dimensional collagen matrices
(University of Missouri--Columbia, 2008)Rho GTPases regulate a diverse spectrum of cellular functions involved in vascular morphogenesis. Here, we show that Cdc42 and Rac1 play a key role in endothelial cell (EC) lumen and tube formation in 3D collagen matrices, ... -
A study of SecA: the motor of the bacterial secretion system by site-directed spin labeling and EPR
(University of Missouri--Columbia, 2008)For more than 3 decades, the biochemical details of the Sec system of protein export have been teased out of Escherichia coli. Through these efforts we know that SecA, the ATPase of the Sec system, interacts with several ... -
Substrate activation in the urate oxidase reaction
(University of Missouri--Columbia, 2008)The enzyme urate oxidase (UO) is involved in nitrogen metabolism of many organisms. Urate oxidation is carried out by UO without the aid of a metal ion or cofactor. A catalytic diad has previously been proposed to be ... -
Two aspects of peripheral immune tolerance: systemic and mucosal tolerance mechanisms
(University of Missouri--Columbia, 2008)Autoimmune diseases are a significant cause of human morbidity and mortality. The defects in immune system that lead to the pathogenesis of autoimmune disease have not been entirely characterized. Autoimmunity develops ...