Browsing School of Medicine (MU) by Thesis Semester "2015 Spring"
Now showing items 1-9 of 9
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The cellular immune response to murine lyme borreliosis
(University of Missouri--Columbia, 2015)Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi. There are approximately 300,000 new cases of Lyme Disease reported in the United States each year. Individuals with Lyme disease often suffer from ... -
Development of genome-wide genetic assays in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2015)Illumina sequencing and other massively-parallel, short read sequencing technologies have become prevalent methods for querying the genetic systems of organisms. This trend was initially driven by the demand for general ... -
Grasping pressures and phalangeal curvature in primates : an experimental in vivo approach
(University of Missouri--Columbia, 2015)Phalangeal curvature is often used to infer arboreal locomotion in fossil primate species. This is based off an hypothesis of plasticity linked to a loading model that suggests that, when flexed during grasping, a curved ... -
Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation by RNA-binding proteins such as HuR fine tunes gene expression in T cells leading to powerful effects on immune ... -
Probing the viral replication of HCV and XMRV : biochemical characterization, inhibition kinetics and role of host proteins in viral replication
(University of Missouri--Columbia, 2015)The studies described in this thesis focus on RNA viruses XMRV and HCV. In Chapter II we focused on Xenotropic Murine leukemia-Related Virus (XMRV). We characterized the biochemical activity and kinetics of the XMRV reverse ... -
Role of T cell receptor signaling in CD8 T cell memory
(University of Missouri--Columbia, 2015)The generation of immunological memory is the basis for vaccination. The development of memory CD8 T cells is required for long-term protection against intracellular pathogens, such as viruses, and tumors. While the ... -
Role of the P2Y2 nucleotide receptor in inflammation and inflammatory diseases
(University of Missouri--Columbia, 2015)Nucleotides are released from cells in response to tissue damage and activate P2X and P2Y receptors on the cell surface to regulate inflammation, a critical process for wound repair. During inflammation, leukocytes are ... -
The scaffold protein POSH regulates T lymphocyte function
(University of Missouri--Columbia, 2015)T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, ... -
Transient collagen triple-helix binding to membrane type 1 matrix metalloproteinase : interaction studies and NMR-guided structural docking
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] MT1-MMP (MMP-14) as pericellular collagenase is critically involved in cancer cell invasion through collagen barriers that it degrades. To better ...